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Genetically modified Rats:

Combining outstanding rat physiology with innovative technologies in transgenesis
  RAT IS A RELEVANT TOOL FOR STUDYING HUMAN DISEASES
The rat is currently the first experimental animal model for scientists: more publications are using rats than mice (PubMed). Given the similarity between rat and human physiology, the rat is a crucial animal model for the study of many human pathologies such as cardiovascular diseases, ageing, cancer, obesity and diabetes.
A GENETICALLY MODIFIED RAT SAVES TIME
Quicker read-out of experiments
Cell producing cytokine detection down from 2 days to 3 hours
Higher throughput of experiments
in vivo testing of kinase inhibitors: 5 time more compounds a week
A GENETICALLY MODIFIED RAT SAVES MONEY
Simpler & cheaper detection systems
Fluorescent proteins
etc.
Standardized & robust detection
Standard antibodies
etc.

genOway guarantees
Delivery of both PCR and Southern Blot characterized founders
Development deadlines
Achievement of each technical milestones
Worldwide delivery of SPF/SOPF certified rats
You only pay
for what has been done
  GENETICALLY MODIFIED RAT CREATION IS SECURED BY GENOWAY
Rat expertise at genOway
genOway achieved world’s first cloned rat (Zhou et al, Science 2003) Budget gain up to 40% Mouse Rat Period
Wide portfolio of transgenic rat technologies: Tissue specific & spatio-temporal expression technologies, ADMET studies, etc.
Research programs on Knock-out and Knock-in rat models with nuclear transfer technology
Development of long-term in vitro culture techniques of rat embryos
Transgenic rat line belongs to the customer
The customer retains all intellectual property rights over the model
genOway has no claim on either the model or the results generated

Applications

PHYSIOLOGICAL STUDIES:
Tissue Specific & Spatio-Temporal expression
genOway patented rat technologies enable the development of rat model expressing your transgene
In a tissue-specific manner
At a specific time
Applications
Target validation / Gene functions
Disease Models
etc.
GENETIC STUDIES:
QTL deciphering, etc.
The transgenic rat helps you decipher genetic mechanisms
Applications
Validate gene(s) responsible for phenotypes associated with QTL
Decipher genetic regulations: feedback loops, modulators
etc.
IN VIVO STUDIES:
Easy and reliable read-out
Transgenic rat provides relevant models for in vivo studies:
Safety Toxicology studies
Compound specificity & efficacy testing
Molecular studies: regulatory elements, modulators,...
BIBLIOGRAPHY
Cardiovascular diseases - Herrera et al, J Clin Invest 1998 - Hammes et al, Circ Res 1998 - Herrera et al, Nat Med 1999 - Schinke et al, Proc Natl Acad Sci 1999 - Nagasaki et al, J Endocrinol 2002 - Yamaguchi et al, J Cell Biochem 200 - etc. - Genetic diseases - Gariepy et al, J Clin Invest 1998 - Kobayashi et al, PNAS 1997 - Sereda et al, Neuron 1996 - Flavell et al, Embo J 1996 - von Horsten et al, Hum Mol Genet 2003 - etc. - Immunology - Egwuagu et al, Clin Immunol 1999 - Iwamoto et al, J Biol Chem 2002 - Braudeau et al, Exp Biol Med 2003 - Keppler et al, J Exp Med 2002 - etc. - Neuroscience - Czech et al, Neuroscience 1998 - Yamazaki et al, Science 2000 - Sawamoto et al, J Neurosci 2001 - Vezzani et al, Neuroscience 2002 - von Horsten et al, Hum Mol Genet 2003 - etc. - Oncology - Kobayashi et al, PNAS 1997 - Takahashi et al, Transgenic Res 1999 - Asamoto et al, Cancer Res 2001 - Tanaka et al, Transgenic Res 2003 - etc. - Physiology - Flavell et al, Embo J 1996 - Alhonen et al PNAS, 2000 - Ogawa et al, J Biol Chem 2000 - Lamont et al, Diabetologia. 2003 - etc.
For more information,
please e-mail us at info@genoway.com or visit our information request page
Transgenics (rat and mouse gene modification): knockout mouse (KO mouse), knock in mice (KI mice) and transgenic mouse
genOway, service provider in transgenesis for customized genetically modified mice and rats: gene overexpression, gene knockdown, gene knockout, etc.
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