Publications 2021

genOway - Client publication 2021

genOway has been acknowledged in numerous articles for the generation of mouse, rat, and cell line models.

Here, a selection of these publications:

Christian Hundhausen, Rebekka Schneckmann, Yanina Ostendorf, Jacqueline Rimpler, Anette von Glinski, Christina Kohlmorgen, Nina Pasch, Luca Rolauer, Florian von Ameln, Olaf Eckermann, Joachim Altschmied, Niloofar Ale-Agha, Judith Haendeler, Ulrich Flögel, Jens W Fischer, Maria Grandoch.
Endothelial hyaluronan synthase 3 aggravates acute colitis in an experimental model of inflammatory bowel disease.
Matrix Biol. 2021 Aug 28

Tina Schreiber, Maren Falk-Paulsen, Jan Kuiper, Konrad Aden, Rainer Noth, Nicolas Gisch, Stefan Schreiber, Philip Rosenstiel, Burkhard Bewig.
IL23R on myeloid cells is involved in murine pulmonary granuloma formation.
Exp Lung Res. 2021 Aug 18

Noureddine Ben Khalaf, Wedad Al-Mashoor, Azhar Saeed, Wassim Raslan, Halla Bakheit, Ameera Abdulhadi, Ammar Marouani, Safa Taha, Moiz Bakhiet, M Dahmani Fathallah.
Knocking down Israa, the Zmiz1 intron-nested gene, unveils interrelated T cell activation functions in mouse.
Biochem Biophys Rep. 2021 Aug 9

Christoph S Clemen, Andreas Schmidt, Lilli Winter, Fabio Canneva, Ilka Wittig, Lore Becker, Roland Coras, Carolin Berwanger, German Mouse Clinic Consortium; Andreas Hofmann, Britta Eggers, Katrin Marcus, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabe de Angelis, Marcus Krüger, Stephan von Hörsten, Ludwig Eichinger, Rolf Schröder.
N471D WASH complex subunit strumpellin knock-in mice display mild motor and cardiac abnormalities and BPTF and KLHL11 dysregulation in brain tissue.
Neuropathol Appl Neurobiol. 2021 Jul 27

Marwa Mahmoud, Ian Evans, Laura Wisniewski, Yuen Tam, Claire Walsh, Simon Walker-Samuel, Paul Frankel, Peter Scambler, Ian Zachary.
Bcar1/p130Cas is essential for ventricular development and neural crest cell remodelling of the cardiac outflow tract.
Cardiovasc Res. 2021 Jul 16

Deng Pan, Miles Bichanich, Ian S Wood, Daniel A Hunter, Scott M Tintle, Thomas A Davis, Matthew D Wood, Amy M Moore.
Long Acellular Nerve Allografts Cap Transected Nerve to Arrest Axon Regeneration and Alter Upstream Gene Expression in a Rat Neuroma Model.
Plast Reconstr Surg. 2021 Jul 1

Peter Lehmkuhl, Magdalena Gentz, Andres Caballero Garcia de Otezya, Bodo Grimbacher, Hendrik Schulze-Koops, Alla Skapenko.
Dysregulated immunity in PID patients with low GARP expression on Tregs due to mutations in LRRC32.
Cell Mol Immunol. 2021 Jul

Alex Lipovsky, Peter F Slivka, Zhi Su, Yibing Wang, Stephanie Paulsboe, Joseph Wetter, Marian T Namovic, Donna Gauvin, Denise Perron, Stephen B Gauld, Steven McGaraughty, Eric R Goedken.
ACT1 Is Required for Murine IL-23-Induced Psoriasiform Inflammation Potentially Independent of E3 Ligase Activity.
J Invest Dermatol. 2021 Jul

Olivia Sveidahl Johansen, Tao Ma, Jakob Bondo Hansen, Lasse Kruse Markussen, Renate Schreiber, Laia Reverte-Salisa, Hua Dong, Dan Ploug Christensen, Wenfei Sun, Thorsten Gnad, Iuliia Karavaeva, Thomas Svava Nielsen, Sander Kooijman, Cheryl Cero, Oksana Dmytriyeva, Yachen Shen, Maria Razzoli, Shannon L O'Brien, Eline N Kuipers, Carsten Haagen Nielsen, William Orchard, Nienke Willemsen, Naja Zenius Jespersen, Morten Lundh, Elahu Gosney Sustarsic, Cecilie Mørch Hallgren, Mikkel Frost, Seth McGonigle, Marie Sophie Isidor, Christa Broholm, Oluf Pedersen, Jacob Bo Hansen, Niels Grarup, Torben Hansen, Andreas Kjær, James G Granneman, M Madan Babu, Davide Calebiro, Søren Nielsen, Mikael Rydén, Raymond Soccio , Patrick C N Rensen, Jonas Thue Treebak, Thue Walter Schwartz, Brice Emanuelli, Alessandro Bartolomucci, Alexander Pfeifer, Rudolf Zechner, Camilla Scheele, Susanne Mandrup, Zachary Gerhart-Hines.
Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis.
Cell. 2021 Jun 24

Dustin J Flanagan, Nalle Pentinmikko, Kalle Luopajärvi, Nicky J Willis, Kathryn Gilroy, Alexander P Raven, Lynn Mcgarry, Johanna I Englund, Anna T Webb, Sandra Scharaw, Nadia Nasreddin, Michael C Hodder, Rachel A Ridgway, Emma Minnee, Nathalie Sphyris, Ella Gilchrist, Arafath K Najumudeen, Beatrice Romagnolo, Christine Perret, Ann C Williams, Hans Clevers, Pirjo Nummela, Marianne Lähde, Kari Alitalo, Ville Hietakangas, Ann Hedley, William Clark, Colin Nixon, Kristina Kirschner, E Yvonne Jones, Ari Ristimäki, Simon J Leedham, Paul V Fish, Jean-Paul Vincent, Pekka Katajisto, Owen J Sansom.
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.
Nature. 2021 Jun

Aditi R Saxena, Donal N Gorman, Ryan M Esquejo, Arthur Bergman, Kristin Chidsey, Clare Buckeridge, David A Griffith, Albert M Kim.
Danuglipron (PF-06882961) in type 2 diabetes: a randomized, placebo-controlled, multiple ascending-dose phase 1 trial.
Nat Med. 2021 Jun

Qinchuan Wang, Erick O Hernández-Ochoa, Meera C Viswanathan, Ian D Blum, Danh C Do, Jonathan M Granger, Kevin R Murphy, An-Chi Wei, Susan Aja, Naili Liu, Corina M Antonescu, Liliana D Florea, C Conover Talbot Jr, David Mohr, Kathryn R Wagner, Sergi Regot, Richard M Lovering, Peisong Gao, Mario A Bianchet, Mark N Wu, Anthony Cammarato, Martin F Schneider, Gabriel S Bever, Mark E Anderson.
CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution.
Nat Commun. 2021 May 26

Michael Shum, Chitra A Shintre, Thorsten Althoff, Vincent Gutierrez, Mayuko Segawa, Alexandra D Saxberg, Melissa Martinez, Roslin Adamson, Margaret R Young, Belinda Faust, Raffi Gharakhanian, Shi Su, Karthickeyan Chella Krishnan, Kiana Mahdaviani, Michaela Veliova, Dane M Wolf, Jennifer Ngo, Laura Nocito, Linsey Stiles, Jeff Abramson, Aldons J Lusis, Andrea L Hevener, Maria E Zoghbi, Elisabeth P Carpenter, Marc Liesa.
ABCB10 exports mitochondrial biliverdin, driving metabolic maladaptation in obesity.
Sci Transl Med. 2021 May 19

Rebecca A Helmer, Raul Martinez-Zaguilan, Gurvinder Kaur, Lisa A Smith, Jannette M Dufour, Beverly S Chilton.
Helicase-like transcription factor-deletion from the tumor microenvironment in a cell line-derived xenograft model of colorectal cancer reprogrammed the human transcriptome-S-nitroso-proteome to promote inflammation and redirect metastasis.
PLoS One. 2021 May 19

Anthony S Castanza, Sanja Ramirez, Prem P Tripathi, Ray A M Daza, Franck K Kalume, Jan-Marino Ramirez, Robert F Hevner.
AUTS2 Regulates RNA Metabolism and Dentate Gyrus Development in Mice.
Cereb Cortex. 2021 May 19

Lisa Baker, Moses Tar, Adam H Kramer, Guillermo A Villegas, Rabab A Charafeddine, Olga Vafaeva, Parimala Nacharaju, Joel Friedman, Kelvin P Davies, David J Sharp.
Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration.
JCI Insight. 2021 May 10

Goutam Chandra, Sen Chandra Sreetama, Davi A G Mázala, Karine Charton, Jack H VanderMeulen, Isabelle Richard, Jyoti K Jaiswal.
Endoplasmic reticulum maintains ion homeostasis required for plasma membrane repair.
J Cell Biol. 2021 May 3

Jieru Deng, Chunni Lu, Chuanxin Liu, Sara Oveissi, W Douglas Fairlie, Erinna F Lee, Pamuk Bilsel, Hamsa Puthalakath, Weisan Chen.
Influenza A virus infection-induced macroautophagy facilitates MHC class II-restricted endogenous presentation of an immunodominant viral epitope.
FEBS J. 2021 May

Faik Imeri, Bisera Stepanovska Tanturovska, Stephanie Schwalm, Sarbari Saha, Jinyang Zeng-Brouwers, Herrmann Pavenstädt, Josef Pfeilschifter, Liliana Schaefer, Andrea Huwiler.
Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice.
Matrix Biol. 2021 Apr

Talat H Malik, Daniel P Gitterman 2, Deborah P Lavin, Hannah J Lomax-Browne, E Christina Hiemeyer, Linda B Moran, Katharina Boroviak, H Terence Cook, Alyssa C Gilmore, Mawj Mandwie, Amina Ahmad, Ian E Alexander, Grant J Logan, Kevin J Marchbank, Allan Bradley, Matthew C Pickering.
Gain-of-function factor H-related 5 protein impairs glomerular complement regulation resulting in kidney damage.
Proc Natl Acad Sci U S A. 2021 Mar 30

Maryam Keshavarz, Diethard Tautz.
The imprinted lncRNA Peg13 regulates sexual preference and the sex-specific brain transcriptome in mice.
Proc Natl Acad Sci U S A. 2021 Mar 9

Lukas Huijbregts, Virginie Aiello, Andrea Soggia, Philippe Ravassard, Latif Rachdi, Raphaël Scharfmann, Olivier Albagli.
Culture, differentiation, and transduction of mouse E12.5 pancreatic spheres: an in vitro model for the secondary transition of pancreas development.
Islets. 2021 Mar 4

Anastasia Noël, Bénédicte Foveau, Andréa C LeBlanc.
Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits.
Cell Death Dis. 2021 Mar 1

Berta Alcover-Sanchez, Gonzalo Garcia-Martin, Juan Escudero-Ramirez, Carolina Gonzalez-Riano, Paz Lorenzo, Alfredo Gimenez-Cassina1 Laura Formentini, Pedro de la Villa-Polo, Marta P Pereira, Francisco Wandosell, Beatriz Cubelos.
Absence of R-Ras1 and R-Ras2 causes mitochondrial alterations that trigger axonal degeneration in a hypomyelinating disease model.
Glia. 2021 Mar

Julien C Vantourout, Andrew M Mason, Josephine Yuen, Graham L Simpson, Ghotas Evindar, Letian Kuai, Michael Hobbs, Emma Edgar, Saul Needle, Xiaopeng Bai, Steve Wilson, Paul Scott-Stevens, William Traylen, Kim Lambert, Neil Young, Shenaz Bunally, Scott G Summerfield, Richard Snell, Rakesh Lad, Eric Shi, Steven Skinner, Lisa Shewchuk, Allan J B Watson, Chun-Wa Chung, Sandeep Pal, Dennis A Holt, Lara S Kallander, Joanne Prendergast, Katrina Rivera, David G Washburn, Mark R Harpel, Christopher Arico-Muendel, Albert Isidro-Llobet.
In Vivo Half-Life Extension of BMP1/TLL Metalloproteinase Inhibitors Using Small-Molecule Human Serum Albumin Binders.
Bioconjug Chem. 2021 Feb 17

Valentin Jargaud, Sandy Bour, François Tercé, Xavier Collet, Philippe Valet, Anne Bouloumié, Jean-Claude Guillemot, Pascale Mauriège, Sirpa Jalkanen, Craig Stolen, Marko Salmi, David J Smith, Christian Carpéné.
Obesity of mice lacking VAP-1/SSAO by Aoc3 gene deletion is reproduced in mice expressing a mutated vascular adhesion protein-1 (VAP-1) devoid of amine oxidase activity.
J Physiol Biochem. 2021 Feb

Nguyen Huu Tu, Dane D Jensen, Bethany M Anderson, Elyssa Chen, Nestor N Jimenez-Vargas, Nicole N Scheff, Kenji Inoue, Hung D Tran, John C Dolan, Tamaryn A Meek, Morley D Hollenberg, Cheng Z Liu, Stephen J Vanner, Malvin N Janal, Nigel W Bunnett, Laura E Edgington-Mitchell, Brian L Schmidt.
Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2.
J Neurosci. 2021 Jan 6

 


genOway is author of the following publications:

Vanessa Chenouard, Séverine Remy, Laurent Tesson, Séverine Ménoret, Laure-Hélène Ouiss, Yacine Cherifi, Ignacio Anegon.
Advances in Genome Editing and Application to the Generation of Genetically Modified Rat Models.
Front Genet. 2021 Apr 20.

Henri-Philippe Konan, Loay Kassem, Soleilmane Omarjee, Ausra Surmieliova-Garnès, Julien Jacquemetton, Elodie Cascales, Amélie Rezza, Olivier Trédan, Isabelle Treilleux, Coralie Poulard, Muriel Le Romancer.
ERα-36 Regulates Progesterone Receptor Activity in Breast Cancer.
Breast Cancer Res. 2020 May 19.

Johnston RJ, Su LJ, Pinckney J, Critton D, Boyer E, Krishnakumar A, Corbett M, Rankin AL, Dibella R, Campbell L, Martin GH, Lemar H, Cayton T, Huang RY, Deng X, Nayeem A, Chen H, Ergel B, Rizzo JM, Yamniuk AP, Dutta S, Ngo J, Shorts AO, Ramakrishnan R, Kozhich A, Holloway J, Fang H, Wang YK, Yang Z, Thiam K, Rakestraw G, Rajpal A, Sheppard P, Quigley M, Bahjat KS, Korman AJ.
VISTA is an acidic pH-selective ligand for PSGL-1.
Nature. 2019 Oct.

Labarthe L, Henriquez S, Lambotte O, Di Santo JP, Le Grand R, Pflumio F, Arcangeli ML, Legrand N, Bourgeois C.
Frontline Science: Exhaustion and senescence marker profiles on human T cells in BRGSF-A2 humanized mice resemble those in human samples.
J Leukoc Biol. 2019 Aug 4.

Rezza A, Jacquet C, Le Pillouer A, Lafarguette F, Ruptier C, Billandon M, Isnard Petit P, Trouttet S, Thiam K, Fraichard A, Chérifi Y.
Unexpected genomic rearrangements at targeted loci associated with CRISPR/Cas9-mediated knock-in.
Sci Rep. 2019 Mar 5.

Akbergenov R, Duscha S, Fritz AK, Juskeviciene R, Oishi N, Schmitt K, Shcherbakov D, Teo Y, Boukari H, Freihofer P, Isnard-Petit P, Oettinghaus B, Frank S, Thiam K, Rehrauer H, Westhof E, Schacht J, Eckert A, Wolfer D, Böttger EC.
Mutant MRPS5 affects mitoribosomal accuracy and confers stress-related behavioral alterations.
EMBO Rep. 2018 Sep 20.

Ménoret S, Ouisse LH, Tesson L, Delbos F, Garnier D, Remy S, Usal C, Concordet JP, Giovannangeli C, Chenouard V, Brusselle L, Merieau E, Nerrière-Daguin V, Duteille F, Bellier-Waast F, Fraichard A, Nguyen TH, Anegon I.
Generation of immunodeficient rats with Rag1 and Il2rg gene deletions and human tissue grafting models.
Transplantation. 2018 Apr 24.

Dehairs J, Talebi A, Cherifi Y, Swinnen JV.
CRISP-ID: decoding CRISPR mediated indels by Sanger sequencing.
Sci Rep. 2016 Jul 1.

Renaud JB, Boix C, Charpentier M, De Cian A, Cochennec J, Duvernois-Berthet E, Perrouault L, Tesson L, Edouard J, Thinard R, Cherifi Y, Menoret S, Fontanière S, de Crozé N, Fraichard A, Sohm F, Anegon I, Concordet JP, Giovannangeli C.
Improved Genome Editing Efficiency and Flexibility Using Modified Oligonucleotides with TALEN and CRISPR-Cas9 Nucleases.
Cell Rep. 2016 Feb 24.

Viuff D, Antunes F, Evans L, Cameron J, Dyrnesli H, Thue Ravn B, Stougaard M, Thiam K, Andersen B, Kjærulff S, Howard KA.
Generation of a double transgenic humanized neonatal Fc receptor (FcRn)/albumin mouse to study the pharmacokinetics of albumin-linked drugs.
J Control Release. 2016 Feb 10.

Ménoret S, De Cian A, Tesson L, Remy S, Usal C, Boulé JB, Boix C, Fontanière S, Crénéguy A, Nguyen TH, Brusselle L, Thinard R, Gauguier D, Concordet JP, Cherifi Y, Fraichard A, Giovannangeli C, Anegon I.
Homology-directed repair in rodent zygotes using Cas9 and TALEN engineered proteins.
Sci Rep. 2015 Oct 7.

Sothilingam V, Garcia Garrido M, Jiao K, Buena-Atienza E, Sahaboglu A, Trifunović D, Balendran S, Koepfli T, Mühlfriedel R, Schön C, Biel M, Heckmann A, Beck SC, Michalakis S, Wissinger B, Seeliger MW, Paquet-Durand F.
Retinitis pigmentosa: impact of different Pde6a point mutations on the disease phenotype.
Hum Mol Genet. 2015 Oct 1.

Remy S, Tesson L, Menoret S, Usal C, De Cian A, Thepenier V, Thinard R, Baron D, Charpentier M, Renaud JB, Buelow R, Cost GJ, Giovannangeli C, Fraichard A, Concordet JP, Anegon I.
Efficient gene targeting by homology-directed repair in rat zygotes using TALE nucleases.
Genome Res. 2014 Jul 2.

Ménoret S, Fontanière S, Jantz D, Tesson L, Thinard R, Rémy S, Usal C, Ouisse LH, Fraichard A, Anegon I.
Generation of Rag1-knockout immunodeficient rats and mice using engineered meganucleases.
FASEB J. 2012 Nov 12. [Epub ahead of print]

Satoh-Takayama N, Vosshenrich CA, Lesjean-Pottier S, Sawa S, Lochner M, Rattis F, Mention JJ, Thiam K, Cerf-Bensussan N, Mandelboim O, Eberl G, Di Santo JP.
Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense.
Immunity. 2008 Dec 19;29(6):958-70. doi: 10.1016/j.immuni.2008.11.001. Epub 2008 Dec 11.

Cozzi J, Fraichard A, Thiam K.
Use of genetically modified rat models for translational medicine.
Drug Discov Today 2008; 13: 488-494.

Tesson L, Cozzi J, Menoret S, Remy S, Usal C, Fraichard A, Anegon I.
Transgenic modifications of the rat genome.
Transgenic Res. 2005 Oct;14(5):531-46.

Zhou Q, Renard JP, Le Friec G, Brochard V, Beaujean N, Cherifi Y, Fraichard A, Cozzi J.
Generation of fertile cloned rats by regulating oocyte activation.
Science. 2003 Nov 14;302(5648):1179. Epub 2003 Sep 25.

Article in Book:

"Procedures for somatic cell nuclear transfer in the rat" Jean Cozzi, Eryao Wang, Christelle Jacquet, Alexandre Fraichard, Yacine Cherifi, Qi Zhou. Methods and Protocols, Methods in Molecular Biology, vol 597, Humana Press 2010

"Interference RNA for in vivo knock-down of gene expression or genome-wide screening using shRNA". Petit S, Thiam K. In: Anegon (ed.). Rat genomics: Methods and Protocols, Methods in Molecular Biology, vol 597, @ Humana Press 2010

"Pronuclear DNA injection for the production of transgenic rats". Cozzi J, Fraichard A, Braun V, Gross A-C, Merrouche C, Anegon I, Thiam K. In: Transgenesis, Third Edition. 2008

"in vivo RNA interference: another tool in the Box?" in Non-viral Gene Therapy - Gene design and Delivery. Taira, K.; Kataoka, K.; Niidome, T. (Eds.) @ Springer-verlag Tokyo 2005