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Humanized ICP mouse and cell lines
Humanized PD-1/PD-L1 mouse and cell line
Humanized PD-1 & GITR mouse
T-cell engager
Assess toxicity with ICP
The hOX40 mouse enables the in vivo efficacy assessment and profiling of immuno-oncology agents targeting the human immune checkpoint OX40 in fully immunocompetent mice.
The humanized OX40 mouse model (hOX40) is developed by Knockin at the mouse OX40 locus, and expresses a fully humanized OX40 with a human extracellular, transmembrane and intracellular domain.
Anti-tumor efficacy and tumor-specific immunological memory were proven in MC38 and MB49 tumor models.
hOX40 and mOX40 expression on splenocytes activated with αCD3/αCD28 in presence of mIL-2. Kinetic of hOX40 and mOX40 expression on Treg, conventional CD4 and CD8 T cells. Results are expressed as mean±SD.
Splenic and LN-isolated T cells (CD8+) activated with αCD3/αCD28 and immobilized hOX40L or IgG-Fc. A) Representative histogram, and B) cell proliferation determined by CFSE dilution at day 4. C) mIFN-γ production measured by ELISA in culture supernatant at day 3. Results are expressed as mean±SD. Unpaired T test analyses (Mann-Whitney ** p<0.01, *** p<0.001).
Humanized ICP mouse and cell lines
Humanized PD-1/PD-L1 mouse and cell line
Humanized PD-1 & GITR mouse
T-cell engager
Assess toxicity with ICP
The hGITR/Foxp3 mouse enables the in vivo efficacy assessment and profiling of immuno-oncology agents targeting the human immune checkpoint GITR. The red fluorescent protein regulated under the Foxp3 promoter allows you to efficiently monitor and sort Foxp3-expressing cells from different lymphocyte lineages and lymphoid organs.
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