Related resources and publications
Humanized ICP mouse and cell lines
Humanized PD-1/PD-L1 mouse and cell line
Humanized PD-1 & GITR mouse
T-cell engager
Assess toxicity with ICP
Immuno-oncolology models
The hSTING mouse enables the in vivo assessment of agents and therapies targeting the human immune checkpoint STING in fully immunocompetent mice.
The humanized STING model, developed by Knockin at the mouse STING locus, expresses a full human STING.
Different versions of hSTING models are available:
STING is entirely humanizedPhysiological regulation of the human STINGFully functional mouse immune systemLack of expression of the murine target gene, thus avoiding cross-reactivityhSTING validation*
Cytokine levels were measured in serum from DMXAA- or GSK-compound-treated mice.
Humanized ICP mouse and cell lines
Humanized PD-1/PD-L1 mouse and cell line
Humanized PD-1 & GITR mouse
T-cell engager
Assess toxicity with ICP
Immuno-oncolology models
The hGITR/Foxp3 mouse enables the in vivo efficacy assessment and profiling of immuno-oncology agents targeting the human immune checkpoint GITR. The red fluorescent protein regulated under the Foxp3 promoter allows you to efficiently monitor and sort Foxp3-expressing cells from different lymphocyte lineages and lymphoid organs.
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