Publications 2010

genOway has been acknowledged in numerous articles for the generation of both mouse/rat models. Below, a selection of these publications:

Abdul-Sater AA, Saïd-Sadier N, Lam VM, Singh B, Pettengill MA, Soares F, Tattoli I, Lipinski S, Girardin SE, Rosenstiel P, Ojcius DM.
Enhancement of reactive oxygen species production and chlamydial infection by the mitochondrial Nod-like family member NLRX1.
J Biol Chem. 2010 Dec 31;285(53):41637-45.

Jawhar S, Wirths O, Schilling S, Graubner S, Demuth HU, Bayer TA.
Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate abeta formation, induces behavioral deficits and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice.
J Biol Chem. 2010 Dec 10.

Holland S, Coste O, Zhang DD, Pierre SC, Geisslinger G, Scholich K.
The ubiquitin ligase MYCBP2 regulates transient receptor potential vanilloid receptor 1 (TRPV1)-internalization through inhibition of p38 MAPK signaling.
J Biol Chem. 2010 Nov 23.

Al-Mutairi MS, Cadalbert LC, McGachy HA, Shweash M, Schroeder J, Kurnik M, Sloss CM, Bryant CE, Alexander J, Plevin R.
MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana.
PLoS Pathog. 2010 Nov 11;6(11):e1001192.

Thomas DM, Angoa Pérez M, Francescutti-Verbeem DM, Shah MM, Kuhn DM.
The role of endogenous serotonin in methamphetamine-induced neurotoxicity to dopamine nerve endings of the striatum.
J Neurochem. 2010 Nov.

Zhang M, Brewer AC, Schröder K, Santos CX, Grieve DJ, Wang M, Anilkumar N, Yu B, Dong X, Walker SJ, Brandes RP, Shah AM.
NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis.
Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18121-6.

Magill CK, Moore AM, Borschel GH, Mackinnon SE.
A new model for facial nerve research: the novel transgenic Thy1-GFP rat.
Arch Facial Plast Surg. 2010 Sep-Oct;12(5):315-20.

Lamacchia C, Palmer G, Bischoff L, Rodriguez E, Talabot-Ayer D, Gabay C.
Distinct roles of hepatocyte- and myeloid cell-derived IL-1 receptor antagonist during endotoxemia and sterile inflammation in mice.
J Immunol. 2010 Aug 15;185(4):2516-24

Martinez P, Thanasoula M, Carlos AR, Gómez-López G, Tejera AM, Schoeftner S, Dominguez O, Pisano DG, Tarsounas M, Blasco MA.
Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites.
Nat Cell Biol. 2010 Aug;12(8):768-80

Wijesekara N, Dai FF, Hardy AB, Giglou PR, Bhattacharjee A, Koshkin V, Chimienti F, Gaisano HY, Rutter GA, Wheeler MB.
Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion.
Diabetologia. 2010 Aug;53(8):1656-68.

Ledonne A, Federici M, Giustizieri M, Pessia M, Imbrici P, Millan MJ, Bernardi G, Mercuri NB.
Trace amines depress D(2)-autoreceptor-mediated responses on midbrain dopaminergic cells.
Br J Pharmacol. 2010 Jul;160(6):1509-20. doi: 10.1111/j.1476-5381.2010.00792.x.

Sun G, Tarasov AI, McGinty J, McDonald A, da Silva Xavier G, Gorman T, Marley A, French PM, Parker H, Gribble F, Reimann F, Prendiville O, Carzaniga R, Viollet B, Leclerc I, Rutter GA.
Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo.
Diabetologia. 2010 May;53(5):924-36. Epub 2010 Mar 11.

Saharinen P, Helotera H, Miettinen J, Norrmen C, D'Amico G, Jeltsch M, Langenberg T, Vandevelde W, Ny A, Dewerchin M, Carmeliet P, Alitalo K.
Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development.
Genes Dev. 2010 May;24(9):875-80.

Songe-Møller L, van den Born E, Leihne V, Vågbø CB, Kristoffersen T, Krokan HE, Kirpekar F, Falnes PØ, Klungland A.
Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding.
Mol Cell Biol. 2010 Apr;30(7):1814-27.

Lamacchia C, Palmer G, Seemayer CA, Talabot-Ayer D, Gabay C.
Enhanced Th1 and Th17 responses and arthritis severity in mice with a deficiency of myeloidcell-specific interleukin-1 receptor antagonist.
Arthritis Rheum. 2010 Feb;62(2):452-62

D'Amico G, Korhonen EA, Waltari M, Saharinen P, Laakkonen P, Alitalo K.
Loss of endothelial Tie1 receptor impairs lymphatic vessel development-brief report.
Arterioscler Thromb Vasc Biol. 2010 Feb;30(2):207-9.