Publications 2011

genOway has been acknowledged in numerous articles for the generation of both mouse/rat models. Below, a selection of these publications:


Drost R, Bouwman P, Rottenberg S, Boon U, Schut E, Klarenbeek S, Klijn C, van der Heijden I, van der Gulden H, Wientjens E, Pieterse M, Catteau A, Green P, Solomon E, Morris JR, Jonkers J.
BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance.
Cancer Cell. 2011 Dec 13.

Linder AE, Davis RP, Burnett R, Watts SW.
Comparison of the function of the serotonin transporter in the vasculature of male and female rats.
Clin Exp Pharmacol Physiol. 2011 May;38(5):314-22. doi: 10.1111/j.1440-1681.2011.05504.x.

Hundahl CA, Luuk H, Ilmjärv S, Falktoft B, Raida Z, Vikesaa J, Friis-Hansen L, Hay-Schmidt A.
Neuroglobin-deficiency exacerbates Hif1A and c-FOS response, but does not affect neuronal survival during severe hypoxia in vivo.
PLoS One. 2011;6(12):e28160. Epub 2011 Dec 2.

Di Cara B, Maggio R, Aloisi G, Rivet JM, Lundius EG, Yoshitake T, Svenningsson P, Brocco M, Gobert A, De Groote L, Cistarelli L, Veiga S, De Montrion C, Rodriguez M, Galizzi JP, Lockhart BP, Cogé F, Boutin JA, Vayer P, Verdouw PM, Groenink L, Millan MJ.
Genetic deletion of trace amine 1 receptors reveals their role in auto-inhibiting the actions of ecstasy (MDMA).
J Neurosci. 2011 Nov 23;31(47):16928-40.

Whelan G, Kreidl E, Wutz G, Egner A, Peters JM, Eichele G.
Cohesin acetyltransferase Esco2 is a cell viability factor and is required for cohesion in pericentric heterochromatin.
EMBO J. 2011 Nov 18. doi: 10.1038/emboj.2011.381.

Shu X, Luhmann UF, Aleman TS, Barker SE, Lennon A, Tulloch B, Chen M, Xu H, Jacobson SG, Ali R, Wright AF.
Characterisation of a C1qtnf5 Ser163Arg Knock-In Mouse Model of Late-Onset Retinal Macular Degeneration.
PLoS One. 2011;6(11):e27433. Epub 2011 Nov 16.

Platt B, Drever B, Koss D, Stoppelkamp S, Jyoti A, Plano A, Utan A, Merrick G, Ryan D, Melis V, Wan H, Mingarelli M, Porcu E, Scrocchi L, Welch A, Riedel G.
Abnormal Cognition, Sleep, EEG and Brain Metabolism in a Novel Knock-In Alzheimer Mouse, PLB1.
PLoS One. 2011;6(11):e27068. Epub 2011 Nov 11.

Sejersted Y, Hildrestrand GA, Kunke D, Rolseth V, Krokeide SZ, Neurauter CG, Suganthan R, Atneosen-Åsegg M, Fleming AM, Saugstad OD, Burrows CJ, Luna L, Bjørås M.
Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia.
Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18802-7. Epub 2011 Nov 7.

Needham LA, Davidson AH, Bawden LJ, Belfield A, Bone EA, Brotherton DH, Bryant S, Charlton MH, Clark VL, Davies SJ, Donald A, Day FA, Krige D, Legris V, McDermott J, McGovern Y, Owen J, Patel SR, Pintat S, Testar RJ, Wells GM, Moffat D, Drummond AH.
Drug targeting to monocytes and macrophages using esterase-sensitive chemical motifs.
J Pharmacol Exp Ther. 2011 Oct;339(1):132-42. Epub 2011 Jul 21.

Husse J, Zhou X, Shostak A, Oster H, Eichele G.
Synaptotagmin10-Cre, a driver to disrupt clock genes in the SCN.
J Biol Rhythms. 2011 Oct;26(5):379-89. doi: 10.1177/0748730411415363.

Haj-Yasein NN, Vindedal GF, Eilert-Olsen M, Gundersen GA, Skare Ø, Laake P, Klungland A, Thorén AE, Burkhardt JM, Ottersen OP, Nagelhus EA.
Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet.
Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17815-20. Epub 2011 Oct 11.

Liu S, Leask A.
CCN2 is not required for skin development.
J Cell Commun Signal. 2011 Aug;5(3):179-82. Epub 2011 May 1.

Andreas F. Kolb, Reinhard C. Huber, Simon G. Lillico, Ailsa Carlisle, Claire J. Robinson, Claire Neil, Linda Petrie, Dorte B. Sorensen, I. Anna S. Olsson, C. Bruce A. Whitelaw.
Milk Lacking α-Casein Leads to Permanent Reduction in Body Size in Mice.
PlosOne. 2011 July 18 ; 6(7): e21775.

Daroszewska A, van 't Hof RJ, Rojas JA, Layfield R, Landao-Basonga E, Rose L, Rose K, Ralston SH.
A point mutation in the ubiquitin-associated domain of SQSMT1 is sufficient to cause a Paget's disease-like disorder in mice.
Hum Mol Genet. 2011 Jul 15;20(14):2734-44.

Stoppelkamp S, Bell HS, Palacios-Filardo J, Shewan DA, Riedel G, Platt B.
In vitro modelling of Alzheimer's disease: degeneration and cell death induced by viral delivery of amyloid and tau.
Exp Neurol. 2011 Jun;229(2):226-37. doi: 10.1016/j.expneurol.2011.01.018. Epub 2011 Feb 2.

Lelan F, Boyer C, Thinard R, Rémy S, Usal C, Tesson L, Anegon I, Neveu I, Damier P, Naveilhan P, Lescaudron L.
Effects of Human Alpha-Synuclein A53T-A30P Mutations on SVZ and Local Olfactory Bulb Cell Proliferation in a Transgenic Rat Model of Parkinson Disease.
Parkinsons Dis. 2011;2011:987084. Epub 2011 Jun 28.

Patrick Davis R, Linder AE, Watts SW.
Lack of the serotonin transporter (SERT) reduces the ability of 5-hydroxytryptamine to lower blood pressure.
Naunyn Schmiedebergs Arch Pharmacol. 2011 May;383(5):543-6. doi: 10.1007/s00210-011-0622-1. Epub 2011 Mar 30.

Schilling S, Kohlmann S, Bäuscher C, Sedlmeier R, Koch B, Eichentopf R, Becker A, Cynis H, Hoffmann T, Berg S, Freyse EJ, von Hörsten S, Rossner S, Graubner S, Demuth HU.
Glutaminyl Cyclase Knock-out Mice Exhibit Slight Hypothyroidism but No Hypogonadism: IMPLICATIONS FOR ENZYME FUNCTION AND DRUG DEVELOPMENT.
J Biol Chem. 2011 Apr 22;286(16):14199-208.

Lawan A, Al-Harthi S, Cadalbert L, McCluskey AG, Shweash M, Grassia G, Grant A, Boyd M, Currie S, Plevin R.
Deletion of the Dual Specific Phosphatase-4 (DUSP-4) Gene Reveals an Essential Non-redundant Role for MAP Kinase Phosphatase-2 (MKP-2) in Proliferation and Cell Survival.
J Biol Chem. 2011 Apr 15;286(15):12933-43

Rutten K, De Vry J, Bruckmann W, Tzschentke TM.
Pharmacological blockade or genetic knockout of the NOP receptor potentiates the rewarding effect of morphine in rats.
Drug Alcohol Depend. 2011 Apr 1;114(2-3):253-6. Epub 2010 Nov 20.

Ren W, Watts SW, Fanburg BL.
Serotonin transporter interacts with the PDGFβ receptor in PDGF-BB-induced signaling and mitogenesis in pulmonary artery smooth muscle cells.
Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L486-97. Epub 2010 Dec 24.

Rizzi A, Molinari S, Marti M, Marzola G, Calo' G.
Nociceptin/orphanin FQ receptor knockout rats: in vitro and in vivo studies.
Neuropharmacology. 2011 Mar;60(4):572-9. doi: 10.1016/j.neuropharm.2010.12.010. Epub 2010 Dec 22.

Holland S, Coste O, Zhang DD, Pierre SC, Geisslinger G, Scholich K.
The ubiquitin ligase MYCBP2 regulates transient receptor potential vanilloid receptor 1 (TRPV1) internalization through inhibition of p38 MAPK signaling.
J Biol Chem. 2011 Feb 4;286(5):3671-80.

van den Born E, Vågbø CB, Songe-Møller L, Leihne V, Lien GF, Leszczynska G, Malkiewicz A, Krokan HE, Kirpekar F, Klungland A, Falnes PØ.
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA.
Nat Commun. 2011 Feb 1;2:172. doi: 10.1038/ncomms1173.

Liu S, Shi-wen X, Abraham DJ, Leask A.
CCN2 is required for bleomycin-induced skin fibrosis in mice.
Arthritis Rheum. 2011 Jan;63(1):239-46

Thrane AS, Rappold PM, Fujita T, Torres A, Bekar LK, Takano T, Peng W, Wang F, Thrane VR, Enger R, Haj-Yasein NN, Skare O, Holen T, Klungland A, Ottersen OP, Nedergaard M, Nagelhus EA.
Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema.
Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):846-51.