Publications 2012

genOway has been acknowledged in numerous articles for the generation of both mouse/rat models. Below, a selection of these publications:


Della-Zuana O, Audinot V, Levenez V, Ktorza A, Presse F, Nahon JL, Boutin JA.
Peripheral injections of melanin-concentrating hormone receptor 1 antagonist S38151 decrease food intake and body weight in rodent obesity models.
Front Endocrinol (Lausanne). 2012;3:160. doi: 10.3389/fendo.2012.00160. Epub 2012 Dec 21.

Sarzi E, Angebault C, Seveno M, Gueguen N, Chaix B, Bielicki G, Boddaert N, Mausset-Bonnefont AL, Cazevieille C, Rigau V, Renou JP, Wang J, Delettre C, Brabet P, Puel JL, Hamel CP, Reynier P, Lenaers G.
The human OPA1delTTAG mutation induces premature age-related systemic neurodegeneration in mouse.
Brain. 2012 Dec;135(Pt 12):3599-613. doi: 10.1093/brain/aws303.

Bickert T, Marshall RP, Zhang Z, Ludewig P, Binder M, Klinke A, Rottbauer W, Amling M, Wagener C, Ito WD, Horst AK.
Acceleration of collateral development by carcinoembryonic antigen-related cell adhesion molecule 1 expression on CD11b/⁺Gr-1⁺ myeloid cells--brief report.
Arterioscler Thromb Vasc Biol. 2012 Nov.

Swain MD, Orzechowski KL, Swaim HL, Jones YL, Robl MG, Tinaza CA, Myers MJ, Jhingory MV, Buckely LE, Lancaster VA, Yancy HF.
P-gp substrate-induced neurotoxicity in an Abcb1a knock-in/Abcb1b knock-out mouse model with a mutated canine ABCB1 targeted insertion.
Res Vet Sci. 2012 Nov 24. pii: S0034-5288(12)00328-1. doi: 10.1016/j.rvsc.2012.10.025. [Epub ahead of print]

Clement JP, Aceti M, Creson TK, Ozkan ED, Shi Y, Reish NJ, Almonte AG, Miller BH, Wiltgen BJ, Miller CA, Xu X, Rumbaugh G.
Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses.
Cell. 2012 Nov 9;151(4):709-23. doi: 10.1016/j.cell.2012.08.045.

Caparrós-Martín JA, Valencia M, Reytor E, Pacheco M, Fernandez M, Perez-Aytes A, Gean E, Lapunzina P, Peters H, Goodship JA, Ruiz-Perez VL.
The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia.
Hum Mol Genet. 2012 Nov 1.

Turco MY, Furia L, Dietze A, Fernandez Diaz L, Ronzoni S, Sciullo A, Simeone A, Constam D, Faretta M, Lanfrancone L.
Cellular heterogeneity during embryonic stem cell differentiation to epiblast stem cells is revealed by the ShcD/RaLP adaptor protein.
Stem Cells. 2012 Nov;30(11):2423-36. doi: 10.1002/stem.1217.

Orzechowski KL, Swain MD, Robl MG, Tinaza CA, Swaim HL, Jones YL, Myers MJ, Yancy HF.
Neurotoxic effects of ivermectin administration in genetically engineered mice with targeted insertion of the mutated canine ABCB1 gene.
Am J Vet Res. 2012 Sep;73(9):1477-84. doi: 10.2460/ajvr.73.9.1477.

Imrie H, Viswambharan H, Sukumar P, Abbas A, Cubbon RM, Yuldasheva N, Gage M, Smith J, Galloway S, Skromna A, Rashid ST, Futers TS, Xuan S, Gatenby VK, Grant PJ, Channon KM, Beech DJ, Wheatcroft SB, Kearney MT.
Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice.
Diabetes. 2012 Sep;61(9):2359-68. doi: 10.2337/db11-1494. Epub 2012 Jun 25.

Kollmann K, Damme M, Markmann S, Morelle W, Schweizer M, Hermans-Borgmeyer I, Röchert AK, Pohl S, Lübke T, Michalski JC, Käkelä R, Walkley SU, Braulke T.
Lysosomal dysfunction causes neurodegeneration in mucolipidosis II 'knock-in' mice.
Brain. 2012 Sep;135(Pt 9):2661-75. doi: 10.1093/brain/aws209.

Kovacevic I, Hu J, Siehoff-Icking A, Opitz N, Griffin A, Perkins AC, Munn AL, Müller-Esterl W, Popp R, Fleming I, Jungblut B, Hoffmeister M, Oess S.
The F-BAR protein NOSTRIN participates in FGF signal transduction and vascular development.
EMBO J. 2012 Aug 1;31(15):3309-22. doi: 10.1038/emboj.2012.176. Epub 2012 Jun 29.

Sun HH, Saheb-Al-Zamani M, Yan Y, Hunter DA, Mackinnon SE, Johnson PJ.
Geldanamycin accelerated peripheral nerve regeneration in comparison to FK-506 in vivo.
Neuroscience. 2012 Oct 25;223:114-23. doi: 10.1016/j.neuroscience.2012.07.026. Epub 2012 Jul 24.

Chen CM, Bentham J, Cosgrove C, Braganca J, Cuenda A, Bamforth SD, Schneider JE, Watkins H, Keavney B, Davies B, Bhattacharya S.
Functional Significance of SRJ Domain Mutations in CITED2.
PLoS One. 2012;7(10):e46256. doi: 10.1371/journal.pone.0046256. Epub 2012 Oct 17.

da Silva Xavier G, Mondragon A, Sun G, Chen L, McGinty JA, French PM, Rutter GA.
Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice.
Diabetologia. 2012 Oct;55(10):2667-76. doi: 10.1007/s00125-012-2600-7. Epub 2012 Jun 21.

Dey A, Seshasayee D, Noubade R, French DM, Liu J, Chaurushiya MS, Kirkpatrick DS, Pham VC, Lill JR, Bakalarski CE, Wu J, Phu L, Katavolos P, LaFave LM, Abdel-Wahab O, Modrusan Z, Seshagiri S, Dong K, Lin Z, Balazs M, Suriben R, Newton K, Hymowitz S, Garcia-Manero G, Martin F, Levine RL, Dixit VM.
Loss of the tumor suppressor BAP1 causes myeloid transformation.
Science. 2012 Sep 21;337(6101):1541-6. Epub 2012 Aug 9.

Zecharia AY, Yu X, Götz T, Ye Z, Carr DR, Wulff P, Bettler B, Vyssotski AL, Brickley SG, Franks NP, Wisden W.
GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness.
J Neurosci. 2012 Sep 19;32(38):13062-75.

Kolb AF, Sorrell D, Lassnig C, Lillico S, Carlisle A, Neil C, Robinson C, Müller M, Whitelaw CB.
Mammary gland development is delayed in mice deficient for aminopeptidase N.
Transgenic Res. 2012 Sep 15. [Epub ahead of print]

Martin J, Maurhofer O, Bellance N, Benard G, Graber F, Hahn D, Galinier A, Hora C, Gupta A, Ferrand G, Hoppeler H, Rossignol R, Dufour JF, St-Pierre MV.
Disruption of the histidine triad nucleotide-binding hint2 gene in mice affects glycemic control and mitochondrial function.
Hepatology. 2012 Sep 7. doi: 10.1002/hep.26060. [Epub ahead of print]

Wils H, Kleinberger G, Pereson S, Janssens J, Capell A, Van Dam D, Cuijt I, Joris G, De Deyn PP, Haass C, Van Broeckhoven C, Kumar-Singh S.
Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice.
J Pathol. 2012 Sep;228(1):67-76. doi: 10.1002/path.4043. Epub 2012 Jun 25.

Damrath E, Heck MV, Gispert S, Azizov M, Nowock J, Seifried C, Rüb U, Walter M, Auburger G.
ATXN2-CAG42 sequesters PABPC1 into insolubility and induces FBXW8 in cerebellum of old ataxic knock-in mice.
PLoS Genet. 2012;8(8):e1002920. doi: 10.1371/journal.pgen.1002920. Epub 2012 Aug 30.

Lutzmann M, Grey C, Traver S, Ganier O, Maya-Mendoza A, Ranisavljevic N, Bernex F, Nishiyama A, Montel N, Gavois E, Forichon L, de Massy B, Méchali M.
MCM8- and MCM9-deficient mice reveal gametogenesis defects and genome instability due to impaired homologous recombination.
Mol Cell. 2012 Aug 24;47(4):523-34. doi: 10.1016/j.molcel.2012.05.048. Epub 2012 Jul 5.

Raida Z, Hundahl CA, Kelsen J, Nyengaard JR, Hay-Schmidt A.
Reduced infarct size in neuroglobin-null mice after experimental stroke in vivo.
Exp Transl Stroke Med. 2012 Aug 20;4(1):15. doi: 10.1186/2040-7378-4-15.

Hundahl CA, Fahrenkrug J, Luuk H, Hay-Schmidt A, Hannibal J.
Restricted expression of Neuroglobin in the mouse retina and co-localization with Melanopsin and Tyrosine Hydroxylase.
Biochem Biophys Res Commun. 2012 Aug 17;425(1):100-6. doi: 10.1016/j.bbrc.2012.07.061. Epub 2012 Jul 20.

Duran J, Tevy MF, Garcia-Rocha M, Calbó J, Milán M, Guinovart JJ.
Deleterious effects of neuronal accumulation of glycogen in flies and mice.
EMBO Mol Med. 2012 Aug;4(8):719-29. doi: 10.1002/emmm.201200241. Epub 2012 May 2.

Gutiérrez-Herrero S, Maia V, Gutiérrez-Berzal J, Calzada N, Sanz M, González-Manchón C, Pericacho M, Ortiz-Rivero S, González-Porras JR, Arechederra M, Porras A, Guerrero C.
C3G transgenic mouse models with specific expression in platelets reveal a new role for C3G in platelet clotting through its GEF activity.
Biochim Biophys Acta. 2012 Aug;1823(8):1366-77. doi: 10.1016/j.bbamcr.2012.05.021. Epub 2012 May 29.

Garanto A, Vicente-Tejedor J, Riera M, de la Villa P, Gonzàlez-Duarte R, Blanco R, Marfany G.
Targeted knockdown of Cerkl, a retinal dystrophy gene, causes mild affectation of the retinal ganglion cell layer.
Biochim Biophys Acta. 2012 Aug;1822(8):1258-69. doi: 10.1016/j.bbadis.2012.04.004. Epub 2012 Apr 19.

Ma Z, Siebert AP, Cheung KH, Lee RJ, Johnson B, Cohen AS, Vingtdeux V, Marambaud P, Foskett JK.
Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability.
Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):E1963-71. Epub 2012 Jun 18.

Petrova E, López-Gay JM, Rhiner C, Moreno E.
Flower-deficient mice have reduced susceptibility to skin papilloma formation.
Dis Model Mech. 2012 Jul;5(4):553-61. Epub 2012 Feb 23.

Nogales-Gadea G, Pinós T, Lucia A, Arenas J, Camara Y, Brull A, de Luna N, Martín MA, Garcia-Arumí E, Martí R, Andreu AL.
Knock-in mice for the R50X mutation in the PYGM gene present with McArdle disease.
Brain. 2012 Jul;135(Pt 7):2048-57. Epub 2012 Jun 21.

Daude N, Wohlgemuth S, Brown R, Pitstick R, Gapeshina H, Yang J, Carlson GA, Westaway D.
Knockout of the prion protein (PrP)-like Sprn gene does not produce embryonic lethality in combination with PrP(C)-deficiency.
Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9035-40. Epub 2012 May 22.

Suarez PE, Rodriguez EG, Soundararajan R, Mérillat AM, Stehle JC, Rotman S, Roger T, Voirol MJ, Wang J, Gross O, Pétrilli V, Nadra K, Wilson A, Beermann F, Pralong FP, Maillard M, Pearce D, Chrast R, Rossier BC, Hummler E.
The glucocorticoid-induced leucine zipper (gilz/tsc22d3-2) gene locus plays a crucial role in male fertility.
Mol Endocrinol. 2012 Jun;26(6):1000-13. Epub 2012 May 3.

Hartleben B, Widmeier E, Wanner N, Schmidts M, Kim ST, Schneider L, Mayer B, Kerjaschki D, Miner JH, Walz G, Huber TB.
Role of the polarity protein scribble for podocyte differentiation and maintenance.
PLoS One. 2012;7(5):e36705. Epub 2012 May 7.

Lamacchia C, Rodriguez E, Palmer G, Vesin C, Seemayer CA, Rubbia-Brandt L, Gabay C.
Mice deficient in hepatocyte-specific IL-1Ra show delayed resolution of concanavalin A-induced hepatitis.
Eur J Immunol. 2012 May;42(5):1294-303. doi: 10.1002/eji.201142204.

Hardy AB, Wijesekara N, Genkin I, Prentice KJ, Bhattacharjee A, Kong D, Chimienti F, Wheeler MB.
Effects of high-fat diet feeding on Znt8-null mice: differences between β-cell and global knockout of Znt8.
Am J Physiol Endocrinol Metab. 2012 May;302(9):E1084-96. Epub 2012 Feb 14.

Franquesa M, Herrero E, Torras J, Ripoll E, Flaquer M, Gomà M, Lloberas N, Anegon I, Cruzado JM, Grinyó JM, Herrero-Fresneda I.
Mesenchymal Stem Cell Therapy Prevents Interstitial Fibrosis and Tubular Atrophy in a Rat Kidney Allograft Model.
Stem Cells Dev. 2012 May 18. [Epub ahead of print]

Schmeisser MJ, Ey E, Wegener S, Bockmann J, Stempel AV, Kuebler A, Janssen AL, Udvardi PT, Shiban E, Spilker C, Balschun D, Skryabin BV, Dieck St, Smalla KH, Montag D, Leblond CS, Faure P, Torquet N, Le Sourd AM, Toro R, Grabrucker AM, Shoichet SA, Schmitz D, Kreutz MR, Bourgeron T, Gundelfinger ED, Boeckers TM.
Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2.
Nature. 2012 Apr 29;486(7402):256-60. doi: 10.1038/nature11015.

Haymaker CL, Guloglu FB, Cascio JA, Hardaway JC, Dhakal M, Wan X, Hoeman CM, Zaghouani S, Rowland LM, Tartar DM, VanMorlan AM, Zaghouani H.
Bone marrow-derived IL-13Rα,1-positive thymic progenitors are restricted to the myeloid lineage.
J Immunol. 2012 Apr 1;188(7):3208-16. Epub 2012 Feb 20.

Hundahl CA, Fahrenkrug J, Hay-Schmidt A, Georg B, Faltoft B, Hannibal J.
Circadian behaviour in neuroglobin deficient mice.
PLoS One. 2012;7(4):e34462. Epub 2012 Apr 5.

Yang Y, Shu X, Liu D, Shang Y, Wu Y, Pei L, Xu X, Tian Q, Zhang J, Qian K, Wang YX, Petralia RS, Tu W, Zhu LQ, Wang JZ, Lu Y.
EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation.
Neuron. 2012 Feb 23;73(4):774-88.

Moore AM, Borschel GH, Santosa KA, Flagg ER, Tong AY, Kasukurthi R, Newton P, Yan Y, Hunter DA, Johnson PJ, Mackinnon SE.
A transgenic rat expressing green fluorescent protein (GFP) in peripheral nerves provides a new hindlimb model for the study of nerve injury and regeneration.
J Neurosci Methods. 2012 Feb 15;204(1):19-27. Epub 2011 Oct 20.