Publications 2013

genOway has been acknowledged in numerous articles for the generation of both mouse/rat models. Below, a selection of these publications:


Grabrucker S, Proepper C, Mangus K, Eckert M, Chhabra R, Schmeisser MJ, Boeckers TM, Grabrucker AM.
The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation.
Exp Neurol. 2013 Dec 29. pii: S0014-4886(13)00381-6.

Lengacher S, Nehiri-Sitayeb T, Steiner N, Carneiro L, Favrod C, Preitner F, Thorens B, Stehle JC, Dix L, Pralong F, Magistretti PJ, Pellerin L.
Resistance to diet-induced obesity and associated metabolic perturbations in haploinsufficient monocarboxylate transporter 1 mice.
PLoS One. 2013 Dec 18;8(12).

Shalata A, Ramirez MC, Desnick RJ, Priedigkeit N, Buettner C, Lindtner C, Mahroum M, Abdul-Ghani M, Dong F, Arar N, Camacho-Vanegas O, Zhang R, Camacho SC, Chen Y, Ibdah M, DeFronzo R, Gillespie V, Kelley K, Dynlacht BD, Kim S, Glucksman MJ, Borochowitz ZU, Martignetti JA.
Morbid obesity resulting from inactivation of the ciliary protein CEP19 in humans and mice.
Am J Hum Genet. 2013 Dec 5.

Lee V, Maguire J.
Impact of inhibitory constraint of interneurons on neuronal excitability.
J Neurophysiol. 2013 Dec.

Adolph TE, Tomczak MF, Niederreiter L, Ko HJ, Böck J, Martinez-Naves E, Glickman JN, Tschurtschenthaler M, Hartwig J, Hosomi S, Flak MB, Cusick JL, Kohno K, Iwawaki T, Billmann-Born S, Raine T, Bharti R, Lucius R, Kweon MN, Marciniak SJ, Choi A, Hagen SJ, Schreiber S, Rosenstiel P, Kaser A, Blumberg RS.
Paneth cells as a site of origin for intestinal inflammation.
Nature. 2013 Nov 14;503(7475):272-6.

Banning A, Regenbrecht CR, Tikkanen R.
Increased activity of mitogen activated protein kinase pathway in flotillin-2 knockout mouse model.
Cell Signal. 2013 Nov 9;26(2):198-207.

Helmer RA, Martínez-Zaguilán R, Dertien JS, Fulford C, Foreman O, Peiris V, Chilton BS.
Helicase-like transcription factor (hltf) regulates g2/m transition, wt1/gata4/hif-1a cardiac transcription networks, and collagen biogenesis.
PLoS One. 2013 Nov 20;8(11):e80461. doi: 10.1371/journal.pone.0080461.

Garanto A, van Beersum SE, Peters TA, Roepman R, Cremers FP, Collin RW.
Unexpected CEP290 mRNA Splicing in a Humanized Knock-In Mouse Model for Leber Congenital Amaurosis.
PLoS One. 2013 Nov 6;8(11):e79369. doi: 10.1371/journal.pone.0079369.

Imudia AN, Wang N, Tanaka Y, White YA, Woods DC, Tilly JL.
Comparative gene expression profiling of adult mouse ovary-derived oogonial stem cells supports a distinct cellular identity.
Fertil Steril. 2013 Nov;100(5):1451-8.

Goettsch C, Babelova A, Trummer O, Erben RG, Rauner M, Rammelt S, Weissmann N, Weinberger V, Benkhoff S, Kampschulte M, Obermayer-Pietsch B, Hofbauer LC, Brandes RP, Schröder K.
NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis.
J Clin Invest. 2013 November 1; 123(11): 4731–4738.

Gulbins E, Palmada M, Reichel M, Lüth A, Böhmer C, Amato D, Müller CP, Tischbirek CH, Groemer TW, Tabatabai G, Becker KA, Tripal P, Staedtler S, Ackermann TF, van Brederode J, Alzheimer C, Weller M, Lang UE, Kleuser B, Grassmé H, Kornhuber J.
Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs.
Nat Med. 2013 Jul;19(7):934-8. doi: 10.1038/nm.3214. Epub 2013 Jun 16.

Crowe J, Aubareda A, McNamee K, Przybycien PM, Lu X, Williams RO, Bou-Gharios G, Saklatvala J, Dean JL.
Heat shock protein b1-deficient mice display impaired wound healing.
PLoS One. 2013 Oct 15;8(10):e77383. doi: 10.1371/journal.pone.0077383.

Hahm E, Li J, Kim K, Huh S, Rogelj S, Cho J.
Extracellular protein disulfide isomerase regulates ligand-binding activity of αMβ2 integrin and neutrophil recruitment during vascular inflammation.
Blood. 2013 May 9;121(19):3789-800, S1-15. doi: 10.1182/blood-2012-11-467985. Epub 2013 Mar 4.

Kim K, Hahm E, Li J, Holbrook LM, Sasikumar P, Stanley RG, Ushio-Fukai M, Gibbins JM, Cho J.
Platelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in mice.
Blood. 2013 Aug 8;122(6):1052-61. doi: 10.1182/blood-2013-03-492504. Epub 2013 Jun 20.

Huntwork-Rodriguez S, Wang B, Watkins T, Ghosh AS, Pozniak CD, Bustos D, Newton K, Kirkpatrick DS, Lewcock JW.
JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis.
J Cell Biol. 2013 Sep 2;202(5):747-63. doi: 10.1083/jcb.201303066. Epub 2013 Aug 26.

Vandenbeuch A, Anderson CB, Parnes J, Enjyoji K, Robson SC, Finger TE, Kinnamon SC.
Role of the ectonucleotidase NTPDase2 in taste bud function.
Proc Natl Acad Sci U S A. 2013 Aug 19. [Epub ahead of print]

Dart DA, Waxman J, Aboagye EO, Bevan CL.
Visualising androgen receptor activity in male and female mice.
PLoS One. 2013 Aug 7;8(8):e71694. doi: 10.1371/journal.pone.0071694. Print 2013.

Hinkel R, Penzkofer D, Zühlke S, Fischer A, Husada W, Xu QF, Baloch E, van Rooij E, Zeiher AM, Kupatt C, Dimmeler S.
Inhibition of MicroRNA-92a Protects Against Ischemia-Reperfusion Injury in a Large Animal Model.
Circulation. 2013 Jul 29. [Epub ahead of print]

Imudia AN, Wang N, Tanaka Y, White YA, Woods DC, Tilly JL.
Comparative gene expression profiling of adult mouse ovary-derived oogonial stem cells supports a distinct cellular identity.
Fertil Steril. 2013 Jul 19. pii: S0015-0282(13)00736-X. doi: 10.1016/j.fertnstert.2013.06.036. [Epub ahead of print]

Helmer RA, Foreman O, Dertien JS, Panchoo M, Bhakta SM, Chilton BS.
Role of helicase-like transcription factor (hltf) in the g2/m transition and apoptosis in brain.
PLoS One. 2013 Jun 24;8(6):e66799. doi: 10.1371/journal.pone.0066799. Print 2013.

Puszyk W, Down T, Grimwade D, Chomienne C, Oakey RJ, Solomon E, Guidez F.
The epigenetic regulator PLZF represses L1 retrotransposition in germ and progenitor cells.
EMBO J. 2013 May 31. doi: 10.1038/emboj.2013.118. [Epub ahead of print]

Sagardoy A, Martinez-Ferrandis JI, Roa S, Bunting KL, Aznar MA, Elemento O, Shaknovich R, Fontán L, Fresquet V, Perez-Roger I, Robles EF, De Smedt L, Sagaert X, Melnick A, Martinez-Climent JA.
Downregulation of FOXP1 is required during germinal center B-cell function.
Blood. 2013 May 23.

Prieur X, Dollet L, Takahashi M, Nemani M, Pillot B, Le May C, Mounier C, Takigawa-Imamura H, Zelenika D, Matsuda F, Fève B, Capeau J, Lathrop M, Costet P, Cariou B, Magré J.
Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2/seipin-deficient mice.
Diabetologia. 2013 May 17. [Epub ahead of print]

Li MM, Nilsen A, Shi Y, Fusser M, Ding YH, Fu Y, Liu B, Niu Y, Wu YS, Huang CM, Olofsson M, Jin KX, Lv Y, Xu XZ, He C, Dong MQ, Rendtlew Danielsen JM, Klungland A, Yang YG.
ALKBH4-dependent demethylation of actin regulates actomyosin dynamics.
Nat Commun. 2013;4:1832. doi: 10.1038/ncomms2863.

Mühle C, Huttner HB, Walter S, Reichel M, Canneva F, Lewczuk P, Gulbins E, Kornhuber J.
Characterization of Acid sphingomyelinase activity in human cerebrospinal fluid.
PLoS One. 2013 May 2;8(5):e62912. doi: 10.1371/journal.pone.0062912. Print 2013.

Saheb-Al-Zamani M, Yan Y, Farber SJ, Hunter DA, Newton P, Wood MD, Stewart SA, Johnson PJ, Mackinnon SE.
Limited regeneration in long acellular nerve allografts is associated with increased Schwann cell senescence.
Exp Neurol. 2013 May 2. pii: S0014-4886(13)00139-8. doi: 10.1016/j.expneurol.2013.04.011. [Epub ahead of print]

Sportoletti P, Varasano E, Rossi R, Bereshchenko O, Cecchini D, Gionfriddo I, Bolli N, Tiacci E, Intermesoli T, Zanghì P, Masciulli A, Martelli MP, Falzetti F, Martelli MF, Falini B.
The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model.
Blood. 2013 Apr 25.

Zeng L, Xiao Q, Chen M, Margariti A, Martin D, Ivetic A, Xu H, Mason J, Wang W, Cockerill G, Mori K, Li JY, Chien S, Hu Y, Xu Q.
Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis.
Circulation. 2013 Apr 23.

Ehrmann I, Dalgliesh C, Liu Y, Danilenko M, Crosier M, Overman L, Arthur HM, Lindsay S, Clowry GJ, Venables JP, Fort P, Elliott DJ.
The Tissue-Specific RNA Binding Protein T-STAR Controls Regional Splicing Patterns of Neurexin Pre-mRNAs in the Brain.
PLoS Genet. 2013 Apr;9(4):e1003474. doi: 10.1371/journal.pgen.1003474. Epub 2013 Apr 25.

Chen J, Martinez J, Milner TA, Buck J, Levin LR.
Neuronal Expression of Soluble Adenylyl Cyclase in the Mammalian Brain.
Brain Res. 2013 Apr 20. pii: S0006-8993(13)00569-6. doi: 10.1016/j.brainres.2013.04.027. [Epub ahead of print]

Pavlovic D, Hall AR, Kennington EJ, Aughton K, Boguslavskyii A, Fuller W, Despa S, Bers DM, Shattock MJ.
Nitric oxide regulates cardiac intracellular Na+ and Ca2+ by modulating Na/K ATPase via PKCε and phospholemman-dependent mechanism.
J Mol Cell Cardiol. 2013 Apr 20. pii: S0022-2828(13)00144-2. doi: 10.1016/j.yjmcc.2013.04.013. [Epub ahead of print]

Galligan JJ, Patel BA, Schneider SP, Wang H, Zhao H, Novotny M, Bian X, Kabeer R, Fried D, Swain GM.
Visceral hypersensitivity in female but not in male serotonin transporter knockout rats.
Neurogastroenterol Motil. 2013 Apr 17. doi: 10.1111/nmo.12133. [Epub ahead of print]

Solberg A, Robertson AB, Aronsen JM, Rognmo O, Sjaastad I, Wisløff U, Klungland A.
Deletion of mouse Alkbh7 leads to obesity.
J Mol Cell Biol. 2013 Apr 8. [Epub ahead of print]

Ryan D, Koss D, Porcu E, Woodcock H, Robinson L, Platt B, Riedel G.
Spatial learning impairments in PLB1Triple knock-in Alzheimer mice are task-specific and age-dependent.
Cell Mol Life Sci. 2013 Mar 28. [Epub ahead of print]

Zhang J, Twelvetrees AE, Lazarus JE, Blasier KR, Yao X, Inamdar NA, Holzbaur EL, Pfister KK, Xiang X.
Establishing a novel knock-in mouse line for studying neuronal cytoplasmic dynein under normal and pathologic conditions.
Cytoskeleton (Hoboken). 2013 Mar 8. doi: 10.1002/cm.21102. [Epub ahead of print]

Taruno A, Vingtdeux V, Ohmoto M, Ma Z, Dvoryanchikov G, Li A, Adrien L, Zhao H, Leung S, Abernethy M, Koppel J, Davies P, Civan MM, Chaudhari N, Matsumoto I, Hellekant G, Tordoff MG, Marambaud P, Foskett JK.
CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes.
Nature. 2013 Mar 6. doi: 10.1038/nature11906. [Epub ahead of print]

Ufartes R, Schneider T, Mortensen LS, Romero MD, Hentrich K, Knoetgen H, Beilinson V, Moebius W, Tarabykin V, Alves F, Pardo LA, Rawlins JN, Stuehmer W.
Behavioural and functional characterization of Kv10.1 (Eag1) knockout mice.
Hum Mol Genet. 2013 Feb 18. [Epub ahead of print]

Simard AR, Gan Y, St-Pierre S, Kousari A, Patel V, Whiteaker P, Morley BJ, Lukas RJ, Shi FD.
Differential modulation of EAE by α9*- and β2*-nicotinic acetylcholine receptors.
Immunol Cell Biol. 2013 Feb 12. doi: 10.1038/icb.2013.1. [Epub ahead of print]

McManaman JL, Bales ES, Orlicky DJ, Jackman M, Maclean PS, Cain S, Crunk AE, Mansur A, Graham CE, Bowman TA, Greenberg AS.
Perilipin-2 Null Mice are Protected Against Diet-Induced Obesity, Adipose Inflammation and Fatty Liver Disease.
J Lipid Res. 2013 Feb 12. [Epub ahead of print]

Villarroel-Espíndola F, Maldonado R, Mancilla H, Vander Stelt K, Acuña A, Covarrubias A, López C, Angulo C, Castro MA, Slebe JC, Durán J, García-Rocha M, Guinovart JJ, Concha II.
Muscle glycogen synthase isoform is responsible for testicular glycogen synthesis: Glycogen overproduction induces apoptosis in male germ cells.
J Cell Biochem. 2013 Feb 5. doi: 10.1002/jcb.24507. [Epub ahead of print]

Ménoret S, Fontanière S, Jantz D, Tesson L, Thinard R, Rémy S, Usal C, Ouisse LH, Fraichard A, Anegon I.
Generation of Rag1-knockout immunodeficient rats and mice using engineered meganucleases.
FASEB J. 2013 Feb;27(2):703-11. doi: 10.1096/fj.12-219907. Epub 2012 Nov 12.

Borroto A, Arellano I, Dopfer EP, Prouza M, Suchànek M, Fuentes M, Orfao A, Schamel WW, Alarcón B.
Nck Recruitment to the TCR Required for ZAP70 Activation during Thymic Development.
J Immunol. 2013 Feb 1;190(3):1103-12. doi: 10.4049/jimmunol.1202055. Epub 2012 Dec 24.

Gouri Shankar Pandey, Sandra C. Tseng, Tom E. Howard, and Zuben E. Sauna
Detection of Intracellular Factor VIII Protein in Peripheral Blood Mononuclear Cells by Flow Cytometry
BioMed Research International, 28 January 2013

Dreses-Werringloer U, Vingtdeux V, Zhao H, Chandakkar P, Davies P, Marambaud P.
CALHM1 controls Ca2+-dependent MEK/ERK/RSK/MSK signaling in neurons.
J Cell Sci. 2013 Jan 23. [Epub ahead of print]

Margariti A, Li H, Chen T, Martin D, Vizcay-Barrena G, Alam S, Karamariti E, Xiao Q, Zampetaki A, Zhang Z, Wang W, Jiang Z, Gao C, Ma B, Chen YG, Cockerill G, Hu Y, Xu Q, Zeng L.
XBP1 mRNA Splicing Triggers an Autophagic Response in Endothelial Cells through BECLIN-1 Transcriptional Activation.
J Biol Chem. 2013 Jan 11;288(2):859-72. doi: 10.1074/jbc.M112.412783. Epub 2012 Nov 26.