Publications 2014

genOway has been acknowledged in numerous articles for the generation of both mouse/rat models. Below, a selection of these publications:

Weston CJ, Shepherd EL, Claridge LC, Rantakari P, Curbishley SM, Tomlinson JW, Hubscher SG, Reynolds GM, Aalto K, Anstee QM, Jalkanen S, Salmi M, Smith DJ, Day CP, Adams DH
Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis.
J Clin Invest. 2014 Dec 22.

Thorens B, Tarussio D, Maestro MA, Rovira M, Heikkilä E, Ferrer J
Ins1 Cre knock-in mice for beta cell-specific gene recombination.
Diabetologia. 2014 Dec 11.

Clemen CS, Stöckigt F, Strucksberg KH, Chevessier F, Winter L, Schütz J, Bauer R, Thorweihe JM, Wenzel D, Schlötzer-Schrehardt U, Rasche V, Krsmanovic P, Katus HA, Rottbauer W, Just S, Müller OJ, Friedrich O, Meyer R, Herrmann H, Schrickel JW, Schröder R
The toxic effect of R350P mutant desmin in striated muscle of man and mouse.
Acta Neuropathol. 2014 Nov 14.

Shih DQ, Zheng L, Zhang X, Zhang H, Kanazawa Y, Ichikawa R, Wallace KL, Chen J, Pothoulakis C, Koon HW, Targan SR
Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis.
Mucosal Immunol. 2014 Nov.

Pagliarani S, Lucchiari S, Ulzi G, Violano R, Ripolone M, Bordoni A, Nizzardo M, Gatti S, Corti S, Moggio M, Bresolin N, Comi GP
Glycogen storage disease type III: A novel Agl knockout mouse model.
Biochim Biophys Acta. 2014 Nov.

Ilmjärv S, Reimets R, Hundahl CA, Luuk H
Effect of light on global gene expression in the neuroglobin-deficient mouse retina.
Biomed Rep. 2014 Nov.

Iqbal AJ, McNeill E, Kapellos TS, Regan-Komito D, Norman S, Burd S, Smart N, Machemer DE, Stylianou E, McShane H, Channon KM, Chawla A, Greaves DR
Human CD68 promoter GFP transgenic mice allow analysis of monocyte to macrophage differentiation in vivo.
Blood. 2014 Oct 9.

Smith ML, Oliveira Souza FG, Bruce KS, Strang CE, Morley BJ, Keyser KT
Acetylcholine receptors in the retinas of the α7 nicotinic acetylcholine receptor knockout mouse
Molecular Vision. 2014 Sep 20.

Moyes AJ, Khambata RS, Villar I, Bubb KJ, Baliga RS, Lumsden NG, Xiao F, Gane PJ, Rebstock AS, Worthington RJ, Simone MI, Mota F, Rivilla F, Vallejo S, Peiró C, Sánchez Ferrer CF, Djordjevic S, Caulfield MJ, MacAllister RJ, Selwood DL, Ahluwalia A, Hobbs AJ
Endothelial C-type natriuretic peptide maintains vascular homeostasis.
J Clin Invest. 2014 Sep 2.

Daniel JM, Penzkofer D, Teske R, Dutzmann J, Koch A, Bielenberg W, Bonauer A, Boon RA, Fischer A, Bauersachs J, van Rooij E, Dimmeler S, Sedding DG.
Inhibition of miR-92a improves re-endothelialization and prevents neointima formation following vascular injury.
Cardiovasc Res. 2014 Sep 1.

Rosendahl A, Niemann G, Lange S, Ahadzadeh E, Krebs C, Contrepas A, van Goor H, Wiech T, Bader M, Schwake M, Peters J, Stahl R, Nguyen G, Wenzel UO
Increased expression of (pro)renin receptor does not cause hypertension or cardiac and renal fibrosis in mice.
Lab Invest. 2014 Aug.

Dodd GT, Worth AA, Nunn N, Korpal AK, Bechtold DA, Allison MB, Myers MG Jr, Statnick MA, Luckman SM
The Thermogenic Effect of Leptin Is Dependent on a Distinct Population of Prolactin-Releasing Peptide Neurons in the Dorsomedial Hypothalamus.
Cell Metab. 2014 Aug 27.

Nilsen A, Fusser M, Greggains G, Fedorcsak P, Klungland A
ALKBH4 Depletion in Mice Leads to Spermatogenic Defects.
PLoS One. 2014 Aug 25.

Plucińska K, Crouch B, Koss D, Robinson L, Siebrecht M, Riedel G, Platt B
Knock-in of human BACE1 cleaves murine APP and reiterates Alzheimer-like phenotypes.
J Neurosci. 2014 Aug 6.

McNeill E, Iqbal AJ, Patel J, White GE, Regan-Komito D, Greaves DR, Channon KM
Contrasting in vitro vs. in vivo effects of a cell membrane-specific CC-chemokine binding protein on macrophage chemotaxis.
J Mol Med (Berl). 2014 Aug 1.

Shih PY, Engle SE, Oh G, Deshpande P, Puskar NL, Lester HA, Drenan RM
Differential expression and function of nicotinic acetylcholine receptors in subdivisions of medial habenula.
J Neurosci. 2014 Jul 16.

Sun Y, Caplazi P, Zhang J, Mazloom A, Kummerfeld S, Quinones G, Senger K, Lesch J, Peng I, Sebrell A, Luk W, Lu Y, Lin Z, Barck K, Young J, Del Rio M, Lehar S9, Asghari V8, Lin W1, Mariathasan S9, DeVoss J1, Misaghi S10, Balazs M1, Sai T5, Haley B, Hass PE, Xu M, Ouyang W, Martin F, Lee WP, Zarrin AA
PILRα negatively regulates mouse inflammatory arthritis.
J Immunol. 2014 Jul 15.

Foronda M, Martínez P, Schoeftner S, Gómez-López G, Schneider R, Flores JM, Pisano DG, Blasco MA
Sox4 Links Tumor Suppression to Accelerated Aging in Mice by Modulating Stem Cell Activation.
Cell Rep. 2014 Jul 15.

Tordoff MG, Ellis HT, Aleman TR, Downing A, Marambaud P, Foskett JK, Dana RM, McCaughey SA
Salty Taste Deficits in CALHM1 Knockout Mice.
Chem Senses. 2014 Jul.

Penzkofer D, Bonauer A, Fischer A, Tups A, Brandes RP, Zeiher AM, Dimmeler S
Phenotypic Characterization of miR-92a-/- Mice Reveals an Important Function of miR-92a in Skeletal Development.
PLoS One. 2014 Jun 30.

Lizarraga LE, Phan AV, Cholanians AB, Herndon JM, Lau SS, Monks TJ
Serotonin reuptake transporter deficiency modulates the acute thermoregulatory and locomotor activity response to 3,4-(±)-methylenedioxymethamphetamine, and attenuates depletions in serotonin levels in SERT-KO rats.
Toxicol Sci. 2014 Jun.

Berger SB, Kasparcova V, Hoffman S, Swift B, Dare L, Schaeffer M, Capriotti C, Cook M, Finger J, Hughes-Earle A, Harris PA, Kaiser WJ, Mocarski ES, Bertin J, Gough PJ
RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice.
J Immunol. 2014 Jun 15.

Thomas PS, Rajderkar S, Lane J, Mishina Y, Kaartinen V
AcvR1-mediated BMP signaling in second heart field is required for arterial pole development: Implications for myocardial differentiation and regional identity.
Dev Biol. 2014 Jun 15.

Fahs SA, Hille MT, Shi Q, Weiler H, Montgomery RR
A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII.
Blood. 2014 Jun 12.

Parra S, Huang X, Charbeneau RA, Wade SM, Kaur K, Rorabaugh BR, Neubig RR
Conditional disruption of interactions between Gαi2 and regulator of G protein signaling (RGS) proteins protects the heart from ischemic injury.
BMC Pharmacol Toxicol. 2014 Jun 5.

Dioszeghy V, Mondoulet L, Dhelft V, Ligouis M, Puteaux E, Dupont C, Benhamou PH
The regulatory T cells induction by Epicutaneous immunotherapy is sustained and mediates long term protection from eosinophilic disorders in peanut sensitized mice.
Clin Exp Allergy. 2014 Mar 25.

Newton K, Dugger DL, Wickliffe KE, Kapoor N, de Almagro MC, Vucic D, Komuves L, Ferrando RE, French DM, Webster J, Roose-Girma M, Warming S, Dixit VM
Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis.
Science. 2014 Mar 21.

Borroto A, Arellano I, Blanco R, Fuentes M, Orfao A, Dopfer EP, Prouza M, Suchànek M, Schamel WW, Alarcón B
Relevance of Nck-CD3 epsilon interaction for T cell activation in vivo.
J Immunol. 2014 Mar 1.

LeBlanc AC, Ramcharitar J, Afonso V, Hamel E, Bennett DA, Pakavathkumar P, Albrecht S
Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment.
Cell Death Differ. 2014 May 21.

Núñez B, Martínez de Mena R, Obregon MJ, Font-Llitjós M, Nunes V, Palacín M, Dumitrescu AM, Morte B, Bernal J
Cerebral cortex hyperthyroidism of newborn mct8-deficient mice transiently suppressed by lat2 inactivation.
PLoS One. 2014 May 12.

Li LC, Wang Y, Carr R, Haddad CS, Li Z, Qian L, Oberholzer J, Maker AV, Wang Q, Prabhakar BS
IG20/MADD Plays a Critical Role in Glucose-Induced Insulin Secretion.
Diabetes. 2014 May.

Polato F, Rusconi P, Zangrossi S, Morelli F, Boeri M, Musi A, Marchini S, Castiglioni V, Scanziani E, Torri V, Broggini M
DRAGO (KIAA0247), a New DNA Damage-Responsive, p53-Inducible Gene That Cooperates With p53 as Oncosupprossor.
J Natl Cancer Inst. 2014 Apr.

Clarke SE, Kang JX, Ma DW
The iFat1 transgene permits conditional endogenous n-3 PUFA enrichment both in vitro and in vivo.
Transgenic Res. 2014 Mar 13.

Borroto A, Arellano I, Blanco R, Fuentes M, Orfao A, Dopfer EP, Prouza M, Suchànek M, Schamel WW, Alarcón B.
Relevance of Nck-CD3{varepsilon} Interaction for T Cell Activation In Vivo.
J Immunol. 2014 Jan 27.

Winkelmann A, Maggio N, Eller J, Caliskan G, Semtner M, Häussler U, Jüttner R, Dugladze T, Smolinsky B, Kowalczyk S, Chronowska E, Schwarz G, Rathjen FG, Rechavi G, Haas CA, Kulik A, Gloveli T, Heinemann U, Meier JC.
Changes in neural network homeostasis trigger neuropsychiatric symptoms.
J Clin Invest. 2014 Jan 16.

Fantin A, Herzog B, Mahmoud M, Yamaji M, Plein A, Denti L, Ruhrberg C, Zachary I.
Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis.
Development. 2014 Jan 8.

Liu S, Thompson K, Leask A.
CCN2 expression by fibroblasts is not required for cutaneous tissue repair.
Wound Repair Regen. 2014 Jan;22(1):119-24.


genOway is the author of the following publications:

Remy S, Tesson L, Menoret S, Usal C, De Cian A, Thepenier V, Thinard R, Baron D, Charpentier M, Renaud JB, Buelow R, Cost GJ, Giovannangeli C, Fraichard A, Concordet JP, Anegon I.
Efficient gene targeting by homology-directed repair in rat zygotes using TALE nucleases.
Genome Res. 2014 Jul 2.

Ménoret S, Fontanière S, Jantz D, Tesson L, Thinard R, Rémy S, Usal C, Ouisse LH, Fraichard A, Anegon I.
Generation of Rag1-knockout immunodeficient rats and mice using engineered meganucleases.
FASEB J. 2012 Nov 12. [Epub ahead of print]

Satoh-Takayama N, Vosshenrich CA, Lesjean-Pottier S, Sawa S, Lochner M, Rattis F, Mention JJ, Thiam K, Cerf-Bensussan N, Mandelboim O, Eberl G, Di Santo JP.
Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense.
Immunity. 2008 Dec 19;29(6):958-70. doi: 10.1016/j.immuni.2008.11.001. Epub 2008 Dec 11.

Cozzi J, Fraichard A, Thiam K.
Use of genetically modified rat models for translational medicine.
Drug Discov Today 2008; 13: 488-494.

Tesson L, Cozzi J, Menoret S, Remy S, Usal C, Fraichard A, Anegon I.
Transgenic modifications of the rat genome.
Transgenic Res. 2005 Oct;14(5):531-46.

Zhou Q, Renard JP, Le Friec G, Brochard V, Beaujean N, Cherifi Y, Fraichard A, Cozzi J.
Generation of fertile cloned rats by regulating oocyte activation.
Science. 2003 Nov 14;302(5648):1179. Epub 2003 Sep 25.

Article in Book:

"Procedures for somatic cell nuclear transfer in the rat" Jean Cozzi, Eryao Wang, Christelle Jacquet, Alexandre Fraichard, Yacine Cherifi, Qi Zhou. Methods and Protocols, Methods in Molecular Biology, vol 597, Humana Press 2010

"Interference RNA for in vivo knock-down of gene expression or genome-wide screening using shRNA". Petit S, Thiam K. In: Anegon (ed.). Rat genomics: Methods and Protocols, Methods in Molecular Biology, vol 597, @ Humana Press 2010

"in vivo RNA interference: another tool in the Box?" in Non-viral Gene Therapy - Gene design and Delivery. Taira, K.; Kataoka, K.; Niidome, T. (Eds.) @ Springer-verlag Tokyo 2005

"Pronuclear DNA injection for the production of transgenic rats". Cozzi J, Fraichard A, Braun V, Gross A-C, Merrouche C, Anegon I, Thiam K. In: Transgenesis, Third Edition. (in press); 2008