Cardiovascular Disease Mouse Models
Our catalog of KO mice contains numerous models displaying cardiovascular disease (CVD) phenotypes that you can appreciate, thanks to a panel of phenotyping tests mandated by the International Mouse Phenotyping Consortium (IMPC) and systematically performed on our lines.
- Heart weight: to evaluate cardiac size
- Eye morphology: to detect blood vessel abnormalities
- Electrocardiogram (ECG): to determine heart rate, potential ECG abnormalities and syndromes in a conscious mouse
- Echocardiogram (echo): to assess the functionality of the heart (ejection fraction, stroke volume…) and identify potential mutant phenotypes
Examples of phenotyped KO lines with CVD phenotypes:
Aoc1, Cidec, Cisd2, Cybrd1, Epb41l5, Fbp2, Grm6, Gsto2, H2-M5, Il17rd, Mbtd1, Mybpc3, Myo10, Pcx, Pink1, Ric1, Ric8, Scarb1, Serf1, Tmem255b, Usp24, Vwa8, Zbtb24…
In humans, a mutation for MYBPC3 gene, the cardiac isoform of myosin-binding protein C, is a cause of familial hypertrophic cardiomyopathy (1) KO mice for its murine homolog Mybpc3 show significant differences with WT in 4 tests including increased heart weight (observed during heart dissection)
Single nucleotide polyorphism in the human SCARB1, a plasma receptor for high density lipoprotein (HDL) cholesterol, contributes to genetic susceptibility to coronary heart disease (2). KO mice for Scarb1 show significant differences with WT in 6 tests including:
About 21 mouse lines KO for genes such as Abca7, Bbs5, Gja8, Ism2, Klhl29, Leprotl1, Lin28b, Mbd5, Pja2, and Uhrf2...
Decreased heart rate variability in transmembrane connexin protein Gja8-/- mice (ECG)
About 32 mouse lines KO for genes such as Anxa3, Cant1, Cyb561, Emc8, Fgfr1op, Mapt, Mfsd8, Ppfia2, Smoc1, and Wsb2...
Increased occurrence of abnormality in both eyes in integral membrane protein Mfsd8-/- mice (eye morphology)
- Watkins, H. et al. Mutations in the cardiac myosin binding protein-C gene on chromosome 11 cause familial hypertrophic cardiomyopathy. Nat. Genet. 11, 434–7 (1995).
- Yoon, Y., Song, J., Hong, S. H. & Kim, J. Q. Analysis of multiple single nucleotide polymorphisms of candidate genes related to coronary heart disease susceptibility by using support vector machines. Clin Chem Lab Med 41, 529–534 (2003).