Neuroscience Mouse Models
Our catalog of KO mice contains numerous models displaying characteristics of neurodegenerative diseases or pain that you can appreciate, thanks to a panel of phenotyping tests mandated by the International Mouse Phenotyping Consortium (IMPC) and systematically performed on our lines.
- Combined SHIRPA and Dysmorphology (CSD): to detect physical, behavioral and morphological abnormalities
- Open field: to assess anxiety and exploratory behaviors
- Acoustic startle and pre-pulse inhibition: to assess sensorimotor gating
- Grip strength: to measure neuromuscular function
- Rotarod: to assess motor coordination and balance
- Hot plate: to assess pain sensitivity
Examples of phenotyped KO lines with neurological phenotypes:
Aldh2, Atn1, Bex2, Brd7, Cib2, Coq2, Cpe, Ect2, Emc10, Fgf10, Golga3, Herc3, Lsm1, Marveld2, Mier1, Nptn, Nxn, Otub1, Pcx, Pitx2, Prkaa2, Ramp1, Sarnp, Synj1…
Allele C of the human gene CLU was identified as a risk factor for late-onset Alzheimer’s disease (AD) (1,2). KO mice for Clu, a model of AD (3), show significant differences with WT in 2 behavioral/neurological tests performed under the IMPC guidelines:
Mutations in the human gene DNAJC6 are associated with a form of early-onset Parkinson’s disease (PD) (4). KO mice for Mier1, transcriptional regulator and neighbor gene of Dnajc6, show significant differences with WT in 7 tests performed under the IMPC guidelines, including:
About 45 mouse lines KO for genes such as Abca13, Cox5b, Dact2, Dst, Eml2, Gpc4, Igfbp7, Muc5ac, Pkia, Taf6...
About 176 mouse lines KO for genes such as Ajap1, Cib2, Elmod1, Fbxo2, Pdss2, Prdm14, Smurf1, Tmem68, Usp2, Whrn...
Increased thermal nociception threshold (time of first response) in cytoskeleton protein Whrn-/- mice (assessed on hot plate)
- Lambert, J.-C. et al. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer’s disease. Nat. Genet. 41, 1094–1099 (2009).
- Harold, D. et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer’s disease. Nat. Genet. 41, 1088–1093 (2009).
- DeMattos, R. B. et al. Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer’s disease. Proc. Natl. Acad. Sci. 99, 10843–10848 (2002).
- Edvardson, S. et al. A deleterious mutation in DNAJC6 encoding the neuronal-specific clathrin-uncoating co-chaperone auxilin, is associated with juvenile parkinsonism. PLoS One 7, (2012).