Conditional Knockout mice

Conditional Knockout (KO) mice define models in which, by means of gene targeting, a gene of interest is:

• Inactivated in specific cell types in a certain tissue; other cell types and tissues exhibit an unmodified, functional gene expression

=> Tissue-specific Knockout mice

• Temporally suppressed at a given time-point in embryonic, post-natal or adult animals

=> Inducible Knockout mice

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This strategy can bypass the limits that are usually observed with constitutive Knockout mouse models (e.g., embryonic lethality, compensatory mechanisms or complex phenotype).

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