Related resources and publications

CD28xVISTA bispecific antibodies in immunotherapy

Safety and activity of a conditionally active cLAG3-IL2

Multispecific CD73/PD-1 targeting

FcγR mouse models for efficacy and PK/PD

CD28-targeting therapies

Drug delivery to the brain (TFRC)

BRGSF-HIS & hFcγR to assess cell depletion

CD3 binding T-cell engagement

Novel PD-1 targeted IL-2Rβ/γ agonist

Humanized Mouse Model of Fcγ Receptors

hPD-1 to evaluate novel cancer therapies

PD-1 & strong tumor growth inhibition

CTLA-4 & survival in a colorectal cancer model

Anti hCD39 to promote anti-tumor immunity

CD3 and BRGSF-HIS to assess IrAEs

BRGSF-HIS & hVISTA for immunotherapies

VISTA in the tumor microenvironment

hSTING & anti-tumor response in cold tumors

BRGSF-HIS & CD3ε in CRS

anti-hVISTA against poorly immunogenic tumors
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Humanized ICP in immuno-oncology
Immuno-oncolology models
Immuno-oncolology models
Humanized mouse models
T-cell engager
Assess toxicity with ICP
T-cell engager
Humanized PD-1 & GITR mouse
T-cell engager CD3
Assess T-cell engager in BRGSF-HIS
Humanized PD-1/PD-L1 mouse and cell line
Humanized HSA/hFcRn mouse
Humanized ICP mouse and cell lines
Assess T-cell engager in BRGSF-HIS
Humanized VISTA mouse & Pharmacokinetics
Humanized cLC model - Bispecific antibody development
Targeting the human CD47/SIRPα axis
BRGSF-HIS as model for acute implant-associated osteomyelitis
VISTA - safety and PK profiling
CD3ε - T-cell engager assessment
TFRC for anti-cancer therapies
Therapeutic efficacy and pharmacokinetics