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Technologies

Technologies

Discover our cutting-edge technologies. From precise gene editing to controlled expression systems, our tools empower groundbreaking research in genetic engineering and preclinical studies. Explore the innovative methods that drive our commitment to advancing scientific understanding.

Our technologies

RMCE: Recombinase-Mediated Cassette Exchange

Recombinase-mediated cassette exchange enables the swapping of large genomic regions and is recommended for the generation of humanized models.

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FLEx: Reference technology for inducible point mutations

The FLEx technology is gold standard for inducible point mutations leading to kinase-dead and functional Knockouts, in a temporal- and tissue-specific manner.

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SSR: Site-Specific Recombination

Site-specific recombination is a gene engineering tool (e.g., Cre-lox and FLP-FRT systems) that relies on recombinases to replace specific DNA sequences.

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TET System: Controlled gene expression

Use tetracycline for reversible and efficient spatiotemporal control of gene expression. This on-demand gene induction mimics disease onset and progression.

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Homologous Recombination

Homologous recombination: A robust and efficient gene targeting technology for humanized, Knockin & conditional Knockout models for human disease studies.

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SMASh: A drug-inducible protein turnover control system

This drug-inducible and reversible protein degradation system is of particular interest to model-targeted protein degradation therapeutic approaches in the preclinical stage.

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IRES: Internal ribosome entry site

IRES allows to co-express of several genes under the control of the same promoter and is considered to be the "go-to" technology for transgene co-expressions.

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CRISPR/Cas9 gene editing

CRISPR/Cas9: structure, mechanisms of action, efficacy, off-target activity, genetic backgrounds, multi-targeting, point-mutations, and large deletions.

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Scientific excellence

From model design to experimental results
Featured in 600+ scientific articles

Collaborative approach

Collaboration with 17 Top Pharmas,
170+ Biotechs and 380+ Academic Institutions

Robust validation data on catalog models

Generated with biopharma partners and in-house

Innovative technologies

and guaranteed freedom to operate

Easy access to models

Models with certified health status from professional breeders in US and Europe