Conditional Knockout mice

Our off-the-shelf conditional Knockout models are well-established, validated and widely used mouse lines.

Vdac1

|

Voltage-dependent anion channel 1

Synonyms:

VDAC-1, Vdac, mVDAC1

Gene ID (NCBI):

22333

Protein function:

Forms channels in the outer mitochondrial membrane allowing transport of ATP, ADP, and other metabolites; key in apoptosis and energy metabolism

Applications:

Used in studies of apoptosis, mitochondrial physiology, and drug targeting

Mtor

|

Mechanistic target of rapamycin kinase

Synonyms:

Frap, RAPT1, RAFT1

Gene ID (NCBI):

56717

Protein function:

Master regulator of cell growth, metabolism, and autophagy

Applications:

Tumorigenesis, metabolic regulation, neurobiology

Dhodh

|

Dihydroorotate dehydrogenase (quinone), mitochondrial

Synonyms:

DHOdehase, DHOdehyd

Gene ID (NCBI):

56749

Protein function:

Catalyzes a key step in de novo pyrimidine synthesis

Applications:

Pyrimidine metabolism, immunology, cancer models

Sez6l

|

Seizure related 6 homolog like

Synonyms:

Sez6-like, Sez6-like protein 1

Gene ID (NCBI):

56747

Protein function:

May modulate synaptic development and plasticity

Applications:

CNS development, behavioral modeling

Dnase2b

|

Deoxyribonuclease II beta

Synonyms:

DLAD, DNase II-like acid DNase beta

Gene ID (NCBI):

56629

Protein function:

Degrades DNA during cell death and terminal differentiation in lens

Applications:

Lens development, apoptosis, DNase

Pex3

|

Peroxisomal biogenesis factor 3

Synonyms:

PEX3

Gene ID (NCBI):

56535

Protein function:

Required for peroxisome membrane biogenesis

Applications:

Peroxisome biogenesis, lipid metabolism

Cib2

|

Calcium and integrin binding protein 2

Synonyms:

CIB2, Calcium and integrin-binding family member 2

Gene ID (NCBI):

56506

Protein function:

Regulates calcium signaling and integrin function

Applications:

Auditory research, calcium signaling, sensory defects

Sec1

|

Sec1 family domain-containing protein 1

Synonyms:

Scfd1, Sly1

Gene ID (NCBI):

56546

Protein function:

Regulates SNARE-mediated vesicle fusion at ER and Golgi

Applications:

Intracellular transport, Golgi-ER dynamics

Nme4

|

NME/NM23 nucleoside diphosphate kinase 4

Synonyms:

NM23-H4, NDPS1

Gene ID (NCBI):

56520

Protein function:

Maintains mitochondrial nucleotide pools for energy metabolism

Applications:

Mitochondrial metabolism, cancer research

Gosr2

|

Golgi SNAP receptor complex member 2

Synonyms:

GOS-28, GS28

Gene ID (NCBI):

56494

Protein function:

Involved in ER-to-Golgi vesicular transport

Applications:

Vesicular trafficking, neurodegenerative disease models

Rnf138

|

Ring finger protein 138

Synonyms:

GID9, NARF

Gene ID (NCBI):

56515

Protein function:

Ubiquitin ligase involved in DNA repair and Wnt signaling

Applications:

Cancer, immune response, ubiquitin system

Gtf2e2

|

General transcription factor IIE, polypeptide 2

Synonyms:

TFEb, TFIIE-beta

Gene ID (NCBI):

68153

Protein function:

Component of general transcription factor TFIIE, involved in RNA Pol II initiation

Applications:

Basal transcription, gene expression

Otub2

|

OTU deubiquitinase, ubiquitin aldehyde-binding 2

Synonyms:

Otubain 2

Gene ID (NCBI):

68149

Protein function:

Deubiquitinating enzyme regulating ubiquitin signaling

Applications:

Ubiquitin biology, inflammation, cancer

Fahd2a

|

Fumarylacetoacetate hydrolase domain containing 2A

Synonyms:

Fahd2

Gene ID (NCBI):

68126

Protein function:

May function in amino acid catabolism or detoxification

Applications:

Amino acid metabolism, detoxification

Arpc4

|

Actin related protein 2/3 complex, subunit 4

Synonyms:

ARC-P4, Arp2/3 complex subunit 4

Gene ID (NCBI):

68089

Protein function:

Component of actin-nucleating ARP2/3 complex

Applications:

Cell motility, cytoskeleton, actin dynamics

Mrnip

|

MRNIP

Synonyms:

Myelin regulatory factor interacting protein

Gene ID (NCBI):

68067

Protein function:

Protects genome integrity by regulating DNA damage repair

Applications:

DNA damage repair, genome stability

Atp5s

|

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s

Synonyms:

ATP5S, ATP synthase subunit s

Gene ID (NCBI):

68055

Protein function:

Structural component of mitochondrial ATP synthase complex

Applications:

Mitochondrial function, oxidative phosphorylation

Retreg3

|

Reticulophagy regulator family member 3

Synonyms:

Fam134c, Reticulophagy regulator family member 3

Gene ID (NCBI):

67998

Protein function:

May be involved in ER-phagy and ER turnover

Applications:

Autophagy, ER homeostasis, cell stress models

Nacc2

|

Nucleus accumbens associated 2

Synonyms:

B230312C02Rik, Nacc family member 2

Gene ID (NCBI):

67991

Protein function:

May act as a transcriptional regulator in brain function

Applications:

Neurodevelopment, behavioral model studies

Tubb6

|

Tubulin, beta 6 class V

Synonyms:

TUBB-6, Tubulin beta-6 chain

Gene ID (NCBI):

67951

Protein function:

Component of microtubules, involved in cell division and structure

Applications:

Cell structure, mitosis, cancer

Myl12b

|

Myosin, light chain 12B, regulatory

Synonyms:

MLC-B, MRLC2, Myosin regulatory light chain 12B

Gene ID (NCBI):

67938

Protein function:

Modulates myosin II function in cell contractility and motility

Applications:

Cytoskeleton, cell migration models

Atp5g2

|

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2

Synonyms:

ATP5G, ATP synthase lipid-binding protein

Gene ID (NCBI):

67942

Protein function:

Involved in ATP synthesis via proton gradient in mitochondria

Applications:

Energy metabolism, mitochondrial research

Pef1

|

PEF1, penta-EF hand domain containing 1

Synonyms:

Peflin, PEF-1

Gene ID (NCBI):

67898

Protein function:

Calcium-binding protein regulating signal transduction and apoptosis

Applications:

Calcium signaling, apoptosis, vesicle transport

Coq10b

|

Coenzyme Q10 homolog B

Synonyms:

Coenzyme Q10 homolog B

Gene ID (NCBI):

67876

Protein function:

Participates in CoQ biosynthesis; involved in mitochondrial oxidative phosphorylation

Applications:

Coenzyme Q metabolism, mitochondrial studies

Snap47

|

Synaptosomal-associated protein 47

Synonyms:

Synaptosomal-associated protein 47, Snap-47

Gene ID (NCBI):

67826

Protein function:

SNARE protein involved in membrane trafficking and exocytosis

Applications:

Neuroscience, synaptic transmission models

Dnajb11

|

DnaJ heat shock protein family B member 11

Synonyms:

ERdj3, Hsp40 family protein

Gene ID (NCBI):

67838

Protein function:

ER-localized co-chaperone; part of the protein folding quality control system

Applications:

ER stress, protein quality control models

Rnls

|

Renalase, FAD-dependent amine oxidase

Synonyms:

C10orf59, renalase, Mox1

Gene ID (NCBI):

67795

Protein function:

Secreted amine oxidase involved in blood pressure regulation and metabolism

Applications:

Hypertension, cardiac research models

Dnajc19

|

DnaJ heat shock protein family (Hsp40) member C19

Synonyms:

DnaJC19, TIM14, Dnajc19 homolog

Gene ID (NCBI):

67713

Protein function:

Mitochondrial import inner membrane translocase; involved in protein folding

Applications:

Mitochondrial import, protein folding models

Aldh3b1

|

Aldehyde dehydrogenase 3 family, member B1

Synonyms:

Aldh3, RIKEN cDNA 2700049A03

Gene ID (NCBI):

67689

Protein function:

Detoxifies aldehydes from lipid peroxidation and oxidative stress

Applications:

Oxidative stress models, detoxification studies

Sdhb

|

Succinate dehydrogenase complex iron sulfur subunit B

Synonyms:

SDH2, Sdhb1

Gene ID (NCBI):

67680

Protein function:

Component of mitochondrial complex II; involved in Krebs cycle and ETC

Applications:

Mitochondrial disease, cancer metabolism

Akt1s1

|

AKT1 substrate 1 (proline-rich)

Synonyms:

PRAS40, 1700031F05Rik

Gene ID (NCBI):

67605

Protein function:

Regulates mTORC1 signaling and insulin sensitivity

Applications:

Cancer metabolism, mTOR studies

Alkbh8

|

AlkB homolog 8, tRNA methyltransferase

Synonyms:

ABH8, R08E3.4, AlkB homolog 8

Gene ID (NCBI):

67667

Protein function:

Catalyzes methylation of tRNA; involved in RNA modification and stress response

Applications:

RNA modification, stress biology

Mxra7

|

Matrix remodeling associated 7

Synonyms:

Matrix remodeling associated 7

Gene ID (NCBI):

67622

Protein function:

Involved in ECM remodeling, potential role in angiogenesis

Applications:

ECM research, fibrosis, angiogenesis

Mgat4c

|

MGAT4C, Glt4c

Synonyms:

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

Gene ID (NCBI):

67569

Protein function:

Glycosyltransferase modifying N-glycan branches

Applications:

Metabolic disorders, glycosylation studies

Cog6

|

Component of oligomeric Golgi complex 6

Synonyms:

Gm1078, 2810033F20Rik

Gene ID (NCBI):

67542

Protein function:

Required for Golgi trafficking and glycoprotein processing

Applications:

Glycosylation, Golgi trafficking models

Ttll4

|

Tubulin tyrosine ligase-like 4

Synonyms:

Tubulin tyrosine ligase-like family, member 4

Gene ID (NCBI):

67534

Protein function:

Adds glutamate residues to tubulin (polyglutamylation)

Applications:

Cilia studies, cytoskeletal modification

Uqcrb

|

Ubiquinol-cytochrome c reductase binding protein

Synonyms:

QP-C, QPc

Gene ID (NCBI):

67530

Protein function:

Component of mitochondrial complex III (electron transport)

Applications:

Mitochondrial dysfunction, metabolic disease models

Ccdc50

|

Coiled-coil domain containing 50

Synonyms:

Ymer

Gene ID (NCBI):

67501

Protein function:

Implicated in EGF signaling, cell proliferation and survival

Applications:

Oncology, EGF pathway, inner ear models

Ufl1

|

UFM1 specific ligase 1

Synonyms:

UFBP1, Maxer

Gene ID (NCBI):

67490

Protein function:

Involved in ufmylation, ER stress response, and hematopoiesis

Applications:

Hematopoiesis, protein modification, ER stress

Polr3g

|

RNA polymerase III subunit G

Synonyms:

RPC7, Gm16207

Gene ID (NCBI):

67486

Protein function:

Component of RNA polymerase III for small RNA transcription

Applications:

Innate immunity, RNA transcription models

Ccdc127

|

Coiled-coil domain-containing 127

Synonyms:

-

Gene ID (NCBI):

67433

Protein function:

Unknown; predicted structural role based on coiled-coil domain

Applications:

Exploratory research, structural studies

Snap29

|

Synaptosomal-associated protein 29

Synonyms:

SNAP-29, Snap-29

Gene ID (NCBI):

67474

Protein function:

SNARE protein involved in vesicle fusion and trafficking

Applications:

Neuroscience, membrane trafficking

Slc47a1

|

Solute carrier family 47 member 1

Synonyms:

Mate1, Mat1

Gene ID (NCBI):

67473

Protein function:

Involved in renal excretion of organic cations and drug metabolites

Applications:

Pharmacokinetics, toxicology, kidney transport

Ears2

|

Glutamyl-tRNA synthetase 2, mitochondrial

Synonyms:

EARS2, Emtuars

Gene ID (NCBI):

67417

Protein function:

Mitochondrial tRNA aminoacylation, protein synthesis

Applications:

Mitochondrial disease, translation studies

Erp29

|

Endoplasmic reticulum protein 29

Synonyms:

ERP-29

Gene ID (NCBI):

67397

Protein function:

Chaperone involved in protein folding in the endoplasmic reticulum

Applications:

ER stress models, protein folding diseases

Inava

|

Innate immune activator

Synonyms:

5730559C18Rik, Inava-like

Gene ID (NCBI):

67313

Protein function:

Regulates epithelial innate immunity and TNF/NF-kB signaling

Applications:

Immunology, inflammation, gut barrier studies

Ndufb8

|

NADH:ubiquinone oxidoreductase subunit B8

Synonyms:

NDUFB8, complex I-B8 subunit

Gene ID (NCBI):

67264

Protein function:

Mitochondrial complex I subunit; involved in oxidative phosphorylation

Applications:

Mitochondrial biology, metabolic disorder models

Cap2

|

Cyclase associated actin cytoskeleton regulatory protein 2

Synonyms:

Cyclase-associated actin cytoskeleton regulatory protein 2

Gene ID (NCBI):

67252

Protein function:

Regulates actin filament dynamics and signal transduction

Applications:

Cytoskeletal research, cardiovascular disease models

Smc6

|

Structural maintenance of chromosomes 6

Synonyms:

SMC-6, Smc6l1

Gene ID (NCBI):

67241

Protein function:

Chromosome organization, DNA repair, replication

Applications:

Genome integrity, DNA replication, meiosis

Zkscan14

|

Zinc finger with KRAB and SCAN domains 14

Synonyms:

Zfp100, Zfp161

Gene ID (NCBI):

67235

Protein function:

Transcriptional regulator via zinc finger DNA-binding motifs

Applications:

Transcription regulation, gene silencing

Med18

|

Mediator complex subunit 18

Synonyms:

Crsp7, Trap29

Gene ID (NCBI):

67219

Protein function:

Transcriptional coactivator within Mediator complex

Applications:

Transcription regulation, developmental biology

Lsm1

|

LSM1 homolog, mRNA degradation associated

Synonyms:

-

Gene ID (NCBI):

67207

Protein function:

Involved in mRNA decapping and degradation

Applications:

mRNA stability, gene expression models

Ubap1

|

Ubiquitin-associated protein 1

Synonyms:

KIAA0162

Gene ID (NCBI):

67123

Protein function:

ESCRT-I complex component, regulates ubiquitin-dependent endosomal sorting

Applications:

Neurodegeneration, vesicle trafficking models

Rnaseh2b

|

Ribonuclease H2 subunit B

Synonyms:

RNASEH2B-like

Gene ID (NCBI):

67153

Protein function:

Removes RNA-DNA hybrids; crucial for genome integrity

Applications:

DNA repair, autoimmune disease models

Ccdc77

|

Coiled-coil domain-containing 77

Synonyms:

-

Gene ID (NCBI):

67200

Protein function:

Function not well known; predicted structural/organizing role

Applications:

Structural protein studies

Atp5e

|

ATP synthase, H+ transporting mitochondrial F1 subunit epsilon

Synonyms:

Atp5kappa

Gene ID (NCBI):

67126

Protein function:

Part of mitochondrial ATP synthase complex; critical for ATP production

Applications:

Metabolism, mitochondrial biology

Bfar

|

Bifunctional apoptosis regulator

Synonyms:

-

Gene ID (NCBI):

67118

Protein function:

Involved in regulation of apoptosis via caspase inhibition

Applications:

Apoptosis, neurobiology, cancer signaling

Fgf22

|

Fibroblast growth factor 22

Synonyms:

-

Gene ID (NCBI):

67112

Protein function:

Promotes synaptogenesis and is involved in skin and hair development

Applications:

Developmental biology, neurobiology, skin regeneration

3110001I22RIK

|

Family with sequence similarity 234, member B

Synonyms:

Fam234b

Gene ID (NCBI):

67118

Protein function:

Putative transmembrane protein; function still under study

Applications:

Basic research, gene function exploration

Ptgr1

|

Prostaglandin reductase 1

Synonyms:

LTB4DH, PGDH1

Gene ID (NCBI):

67103

Protein function:

Inactivates eicosanoids (prostaglandins/leukotrienes)

Applications:

Inflammation, lipid signaling, cancer research

Ctnnbip1

|

Catenin β–interacting protein 1

Synonyms:

ICAT

Gene ID (NCBI):

67087

Protein function:

Inhibits β–catenin–TCF interaction; regulates Wnt signaling

Applications:

Wnt pathway and developmental disease models

Cand2

|

Cullin 2–associated and neddylation–dissociated protein

Synonyms:

TATA‑box‑binding protein–associated factor 13

Gene ID (NCBI):

67088

Protein function:

Cullin–associated regulator; role in ubiquitination and protein turnover

Applications:

Ubiquitin system and muscle biology models

Dynlrb1

|

Dynein light chain roadblock‑type 1

Synonyms:

DYNLRB1

Gene ID (NCBI):

67068

Protein function:

Dynein complex light chain; involved in retrograde transport along microtubules

Applications:

Transport dynamics and neuron models

Actr6

|

Actin‑related protein 6, SWI/SNF complex subunit

Synonyms:

BAF53A

Gene ID (NCBI):

67019

Protein function:

Component of chromatin remodeling complexes; regulates gene expression

Applications:

Epigenetics and chromatin remodeling models

Tbc1d2b

|

TBC1 domain–family member 2B

Synonyms:

Armus, TBC1-domain family member 2B

Gene ID (NCBI):

67016

Protein function:

Rab GAP specific for Rab7; regulates endosome–lysosome traffic

Applications:

Vesicle trafficking and neurobiology models

Yae1d1

|

Yae1 domain–containing protein 1

Synonyms:

Pa2g4ip1

Gene ID (NCBI):

67008

Protein function:

Partner of ribosomal–associated RCC1 methyltransferase; supports ribosome biogenesis/growth

Applications:

Ribosome assembly and growth regulation models

Cisd2

|

CDGSH iron–sulfur domain–containing protein 2

Synonyms:

Miner1, ERIS

Gene ID (NCBI):

67006

Protein function:

Mitochondrial & ER membrane protein; regulates Ca²⁺ homeostasis and redox

Applications:

Aging, mitochondrial & calcium signaling models

Pbrm1

|

PBRM1, SWI/SNF–B chromatin remodeling subunit

Synonyms:

BAF180, Polybromo 1

Gene ID (NCBI):

66923

Protein function:

Part of PBAF complex; binds acetylated histones, modulates transcription

Applications:

Epigenetics and cancer biology models

Ncbp3

|

Nuclear cap–binding complex–interacting protein 3

Synonyms:

CBP80‑interacting protein

Gene ID (NCBI):

66874

Protein function:

Alternative cap-binding protein involved in mRNA export and translation control

Applications:

RNA processing and nuclear export models

Lztr1

|

Leucine zipper–like transcriptional regulator 1

Synonyms:

KLHL24, BTBD15

Gene ID (NCBI):

66863

Protein function:

Cullin-3–based E3 ligase adapter regulating Ras ubiquitination

Applications:

Signal transduction & developmental models

Dnajc10

|

DnaJ heat shock protein family (Hsp40) member C10

Synonyms:

ERdj5, DnaJ homolog subfamily C member 10

Gene ID (NCBI):

66861

Protein function:

ER-resident chaperone; removes misfolded proteins during ERAD

Applications:

Protein quality control and ER stress models

Etfdh

|

Electron transfer flavoprotein dehydrogenase

Synonyms:

ETFDH, ETF-QO, MADD

Gene ID (NCBI):

66841

Protein function:

Transfers electrons from mitochondrial ETF to respiratory chain; vital for fatty acid and amino acid oxidation

Applications:

Mitochondrial fatty acid oxidation models

Acot13

|

Acyl-CoA thioesterase 13

Synonyms:

ACOT13, BCAS2P3 pseudogene

Gene ID (NCBI):

66834

Protein function:

Deactivates fatty acyl-CoAs to free fatty acids and CoA; regulates lipid metabolism

Applications:

Lipid metabolism and energy research

Aspn

|

Asporin

Synonyms:

Asporin, PLAP1

Gene ID (NCBI):

66695

Protein function:

ECM protein in cartilage; regulates collagen fibrillogenesis and TGF-β signaling

Applications:

Cartilage and bone formation models

Snrnp27

|

U4/U6.U5 tri-snRNP 27kDa protein

Synonyms:

SNRP27, SAP27

Gene ID (NCBI):

66618

Protein function:

SNRNP component of spliceosomal U4/U6.U5; crucial for pre-mRNA splicing

Applications:

RNA splicing models

Thg1l

|

tRNA-histidine guanylyltransferase-like protein

Synonyms:

tRNA-histidine guanylyltransferase-like protein

Gene ID (NCBI):

66628

Protein function:

Adds guanosine to 5′ end of tRNA-histidine; key to tRNA functionality

Applications:

tRNA processing and translation models

Farsa

|

Phenylalanine–tRNA synthetase, alpha subunit

Synonyms:

Alanyl-tRNA synthetase, cytoplasmic (AlaRS)

Gene ID (NCBI):

66590

Protein function:

Catalyzes aminoacylation of tRNAs with phenylalanine; essential for translation

Applications:

Translation, neurodegeneration models

Cmpk1

|

Cytidine monophosphate kinase 1

Synonyms:

UMP-CMP kinase, CMPKR1

Gene ID (NCBI):

66588

Protein function:

Buffers UMP and CMP pools by phosphorylation; essential for nucleotide metabolism

Applications:

Nucleotide metabolism and cell cycle models

Crls1

|

Cardiolipin synthase

Synonyms:

TMEM274, Cardiolipin synthase

Gene ID (NCBI):

66586

Protein function:

Catalyzes the synthesis of cardiolipin in the mitochondrial inner membrane

Applications:

Mitochondrial lipid synthesis models

Uqcrh

|

Ubiquinol–cytochrome c reductase hinge protein

Synonyms:

UQCRH, QCR7

Gene ID (NCBI):

66576

Protein function:

Subunit of mitochondrial Complex III; facilitates electron transfer

Applications:

Mitochondrial respiration and energy models

Adamtsl5

|

ADAMTS-like protein 5

Synonyms:

ADAMTS-like 5, cartilage-associated protein

Gene ID (NCBI):

66548

Protein function:

ECM glycoprotein; regulates extracellular matrix organization and cell signaling

Applications:

Extracellular matrix and developmental models

Cul7

|

Cullin 7

Synonyms:

Cullin 7, p185, 3MC syndrome protein

Gene ID (NCBI):

66515

Protein function:

E3 ubiquitin ligase scaffold involved in growth and metabolism regulation

Applications:

Ubiquitination, growth, and developmental models

Chtop

|

Chromatin target of PRMT1

Synonyms:

Chromatin target of PRMT1, C20orf77 ortholog

Gene ID (NCBI):

66511

Protein function:

Regulates RNA export, chromatin architecture, and gene expression

Applications:

Epigenetics and RNA processing models

Fam213b

|

Family with sequence similarity 213 member B

Synonyms:

Thioredoxin-like protein 2 (TXNL2 family member)

Gene ID (NCBI):

66469

Protein function:

Likely redox protein protecting from oxidative stress

Applications:

Redox biology and stress response models

Usmg5

|

ATP synthase membrane subunit OSCP associated protein

Synonyms:

ATP5O, DAPIT

Gene ID (NCBI):

66477

Protein function:

Regulates mitochondrial ATP synthase oligomerization and efficiency

Applications:

Bioenergetics and mitochondrial efficiency models

Pam16

|

Presequence translocase-associated motor 16 kDa

Synonyms:

Magmas, mitochondrial-associated ER membrane protein

Gene ID (NCBI):

66449

Protein function:

Chaperone essential for mitochondrial protein import via the TIM44 complex

Applications:

Protein import and mitochondrial disease models

Tsfm

|

Ts translation elongation factor, mitochondrial

Synonyms:

EF-Ts, MGC57201

Gene ID (NCBI):

66399

Protein function:

Mitochondrial translation elongation factor; essential for mitochondrial protein synthesis

Applications:

Mitochondrial translation models

Fis1

|

FIS1 mitochondrial fission 1

Synonyms:

FIS1, Mitochondrial fission 1 protein

Gene ID (NCBI):

66437

Protein function:

Regulates mitochondrial fission via Drp1 recruitment

Applications:

Mitochondrial dynamics research models

Sar1b

|

SAR1B, small GTPase involved in COPII vesicle budding

Synonyms:

SAR1b, SEC24-interacting

Gene ID (NCBI):

66397

Protein function:

COPII-coated vesicle formation from ER; essential for lipoprotein secretion

Applications:

Lipid transport and secretion models

Chmp4c

|

CHMP4 homolog C (charged multivesicular body protein 4C)

Synonyms:

Charged multivesicular body protein 4C, CHMP4C

Gene ID (NCBI):

66371

Protein function:

ESCRT-III complex subunit; mediates membrane remodeling during cytokinesis and endosomal sorting

Applications:

Cytokinesis and membrane remodeling models

Adprm

|

ADP-ribose/CDP-alcohol diphosphatase

Synonyms:

ADP-ribose/CDP-alcohol diphosphatase

Gene ID (NCBI):

66358

Protein function:

Catalyzes hydrolysis of ADP-ribose; involved in NAD metabolism.

Applications:

NAD metabolism, enzymology models

Dus2

|

Dihydrouridine synthase 2

Synonyms:

DUS2L, Dihydrouridine synthase 2

Gene ID (NCBI):

66369

Protein function:

Catalyzes synthesis of dihydrouridine in tRNA; contributes to tRNA modification.

Applications:

RNA modification, translation fidelity

Blzf1

|

Basic leucine zipper nuclear factor 1

Synonyms:

Basic leucine zipper nuclear factor 1

Gene ID (NCBI):

66352

Protein function:

Transcription factor; may regulate response to cellular stress and apoptosis.

Applications:

Apoptosis, transcriptional regulation

Smurf2

|

SMAD specific E3 ubiquitin protein ligase 2

Synonyms:

Smad ubiquitination regulatory factor 2

Gene ID (NCBI):

66313

Protein function:

E3 ubiquitin ligase that regulates TGF-β signaling via SMAD degradation.

Applications:

Ubiquitin pathway, TGF-β signaling

Sec11c

|

SEC11 homolog C (S. cerevisiae)

Synonyms:

Signal peptidase complex subunit

Gene ID (NCBI):

66286

Protein function:

Part of the signal peptidase complex; cleaves signal peptides from nascent proteins.

Applications:

Secretory pathway, ER signal processing

Tmem126a

|

Transmembrane protein 126A

Synonyms:

Transmembrane protein 126A

Gene ID (NCBI):

66271

Protein function:

Mitochondrial membrane protein involved in Complex I assembly.

Applications:

Complex I assembly, neurodegeneration models

Ssr2

|

Signal sequence receptor subunit 2

Synonyms:

TRAPβ, signal sequence receptor beta

Gene ID (NCBI):

66256

Protein function:

Component of the ER membrane complex that translocates proteins into the ER.

Applications:

ER translocation, protein secretion models

Msmo1

|

Methylsterol monooxygenase 1

Synonyms:

ERG25, Sc4mol

Gene ID (NCBI):

66234

Protein function:

Catalyzes C4-demethylation in cholesterol biosynthesis.

Applications:

Cholesterol biosynthesis, lipid homeostasis

Tmem9

|

Transmembrane protein 9

Synonyms:

Transmembrane protein 9

Gene ID (NCBI):

66241

Protein function:

Participates in lysosomal acidification and vesicle trafficking.

Applications:

Lysosome function, trafficking studies

Ndufb9

|

NADH:ubiquinone oxidoreductase subunit B9

Synonyms:

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9

Gene ID (NCBI):

66218

Protein function:

Subunit of mitochondrial Complex I, involved in electron transport and oxidative phosphorylation.

Applications:

Mitochondrial metabolism, energy disorders

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Sonic hedgehog medulloblastomas

GLP1R

Adult-type granulosa cell tumor (AGCT)

castration-resistant metastatic prostate cancer (mCRPC)

CCR8

Chemokine

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sirp-alpha

CD137

pulmonary embolism (PE)

osteomyelitis

hyperalgesia

PET imaging

intrauterine growth deficiency

Myopia

ossification

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cGAS-STING pathway

TFRC

FX-deficiency

muscle-eye-brain disease (MEB)

Tumor microenvironment

primary immunodeficiency (PID)

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stem cell research

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lymphatic system

learning

heart research

gut research

genetic research

exercise

bone research

embryonic development

dental research

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von Willebrand disease (VWD)

X-linked adrenoleukodystrophy (X-ADL)

Vanishing White Matter (VWM) disease

type 2 diabetes (T2D)

ulcerative colitis (UC)

type 1 diabetes (T1D)

thrombosis

thrombocytopenia

systemic lupus erythematosus (SLE)

tauopathy

stenosis

steatohepatitis

spinocerebellar ataxia type 2 (SCA2)

small cell lung cancer

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Humanized mice (HIS/human immune system)

Address human-specific questions in a more relevant manner, facilitating translational research in several biomedical disciplines and approaches.

Humanized mice (target-specific)

Well-established mouse lines that allow in vivo efficacy and safety assessment of biologics and other compounds.

Cell lines

Our humanized & Knockout ICP cell lines can be used for in vivo tumor growth assays in syngeneic models and in vitro mechanistic studies.

Knockout and reporter models

Our off-the-shelf Knockout & reporter models are well established, validated and widely used mouse and rat lines.

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Models with certified health status from professional breeders in US and Europe