Cell lines

Our humanized & Knockout ICP cell lines can be used for in vivo tumor growth assays in syngeneic models and in vitro mechanistic studies.

Immune checkpoint cell lines

Our humanized and Knockout immune checkpoint cell lines represent cutting-edge advancements in the field of immuno-oncology research. These meticulously engineered cell lines play a pivotal role in unraveling the complexities of immune responses and checkpoint regulation.

The Humanized cell lines are tailored to express human immune checkpoint proteins, providing a more accurate reflection of human immune system behavior.

On the other hand, the Knockout cell lines involve the targeted inactivation of specific immune checkpoint genes, allowing researchers to study the effects of these alterations on immune function.

These innovative cell lines serve as invaluable tools for exploring the intricate mechanisms of immune checkpoint pathways, paving the way for advancements in immunotherapy and contributing significantly to the development of novel therapeutic strategies.

Discover our

Cell lines

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MC38-hPD-L1-LZ

The MC38-hPD-L1-LZ clonal cell line expresses high levels of  human PD-L1 and forms solid tumors in vivo. An optimized version of a  luciferase-ZsGreen (LZ) fusion protein is also stably expressed for in vivo imaging and ex vivo tracking.

Cells
PD-L1
ICP
MC38
PD-1

MC38-hPD-L1-hHER2-LZ

The  MC38-hPD-L1-hHER2-LZ clonal cell line expresses high levels of human PD-L1  and human HER2.

Cells
MC38
ICP
Reporter
PD-L1

MC38-hCD39-LZ

The  MC38-hCD39-LZ cells homogeneously express human CD39 in vitro, and form  infiltrated tumors in immunocompetent mice.

CD39
Cells
MC38
Reporter
ICP

EL4-hCD20-LZ

The  EL4-hCD20-LZ clonal cell line expresses high levels of human CD20.

CD20
Cells
ICP
Reporter
EL4

EL4-hCD19-LZ

EL4-hCD19-LZ cells form tumors in syngeneic models, upon subcutaneous and systemic (i.v.) injection, in immunocompetent mice.

CD19
EL4
Cells
ICP
Reporter

CT26-hEpCAM-LZ

CT26-hEpCAM-LZ  clonal cell line expresses high levels of human EpCAM, and forms solid tumors in vivo.

CT26
Cells
ICP
EpCAM

CT26-hCD39-LZ

The CT26-hCD39-LZ clonal cell line expresses high levels of human/mouse chimeric CD39, and forms solid tumors in vivo.

CT26
Cells
ICP
CD39

CT26-Pd-l1-ko

The Pd-l1 Knockout colon carcinoma CT26 cell line is invalidated for murine Pd-l1 and can be used for target validation and mechanistic studies.

ICP
PD-L1
Knockout
Cells
CT26

MC38-Pd-l1-ko

The Pd-l1 Knockout colon adenocarcinoma MC38 cell line is invalidated for murine Pd-l1 and can be used for target validation and mechanistic studies.

PD-L1
Cells
Knockout
ICP

CT26-hPD-L1

The humanized PD-L1 syngeneic clonal colon carcinoma CT26 cell line expresses high levels of human PD-L1 and forms solid tumors in vivo.

PD-L1
Cells
ICP

MC38-hPD-L1-hCD47-LZ

The MC38-hPD-L1-hCD47-LZ clonal cell line expresses high levels of human PD-L1 and human CD47.

ICP
Cells
PD-L1
CD47
Reporter

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Related ressources et publication

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