Humanized immune checkpoint mouse models

Features

• Physiological expression of the human target(s)
• Preservation of the target-ligand interaction
• Fully functional mouse immune system
• Lack of expression of the murine target gene, thus avoiding cross-reactivity
• Suitable for studying:
• Well-calibrated syngeneic tumor models
• Long-term treatment(s)
• T cell exhaustion and reminiscence

Validation

The ICP mouse models are co-validated by our partners of the precompetitive consortium, including BMS, Charles River, Alligator and more company leaders in immuno-oncology and immunotherapy.