Knockin cell lines

A Knockin cell line defines a cell line in which an exogenous gene is inserted in a native locus of interest.

The inserted gene or gene sequence expression is regulated under the native promoter, which provides a physiologically relevant and secure expression.

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Typical applications for academic research:

• Study gene expression as part of specific functions of signaling pathways
• Study expression of mutated isoforms

For bio-pharmaceutical research & development:

• Expression of targets for compound screening
• Selectivity screening
• Drug affinity testing
• Compound profiling
• Bioproduction
• Comparison of target responses to xenobiotics

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