A Knockin cell line defines a cell line in which an exogenous gene is inserted in a native locus of interest.
The inserted gene or gene sequence expression is regulated under the native promoter, which provides a physiologically relevant and secure expression.
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Typical applications for academic research:
- Study gene expression as part of specific functions of signaling pathways
- Study expression of mutated isoforms
For bio-pharmaceutical research & development:
- Expression of targets for compound screening
- Selectivity screening
- Drug affinity testing
- Compound profiling
- Bioproduction
- Comparison of target responses to xenobiotics
Knockin cell lines
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