A gene Knockin (KI) rat defines a model in which, by means of gene targeting, a gene sequence is inserted at a particular locus.
Since 2002, we have been heavily investing in rat model development (see our history), and have designed a unique CRISPR/Cas9-based offer, combining our:
- Expertise in model design
- Rigorous quality controls for rat models
With the advantages of gene CRISPR/Cas9 technology, such as:
- Cost effectiveness
- Short development time
Your benefits and guarantees:
- Robust design for physiological relevant rat models
- Reliable and reproducible performance in many rat strains, including, but not limited to:
- Inbred: Brown Norway, Fischer 344, Lewis, etc.
- Outbred: Wistar, Long-Evans, Spraque Dawley, etc.
- Freedom to operate thanks to our unique IP portfolio, including licenses from MIT and Merck KGaA
- Rigorous off-target assessment
Basically, two models are very common:
- Point mutation KI
One or more mutated nucleotides causing gain or loss of function of a given protein
- Quick Knockin
Controlled gene expression/copy number by targeting the permissive (neutral) locus Rosa26
Knockin rat models
Get in touch about
Let us know how we can help
Scientific excellence
From model design to experimental results
Tailor-made solutions adapted to scientific questions
Robust validation data on catalog models
Comprehensive dataset package
Generated with biopharma partners and in-house
Customer care
Scientific follow-up and advice along the project
Collaborative approach for problem solving and development of innovative models
Easy and fast access to models
Breeding facilities in US and Europe
Certified health status from professional breeders