Knockin rat models

A gene Knockin (KI) rat defines a model in which, by means of gene targeting, a gene sequence is inserted at a particular locus.

Since 2002, we have been heavily investing in rat model development (see our history), and have designed a unique CRISPR/Cas9-based offer, combining our:

• Expertise in model design
• Rigorous quality controls for rat models

With the advantages of gene CRISPR/Cas9 technology, such as:

• Cost effectiveness
• Short development time

Your benefits and guarantees:

• Robust design for physiological relevant rat models
• Reliable and reproducible performance in many rat strains, including, but not limited to:
• Inbred: Brown Norway, Fischer 344, Lewis, etc.
• Outbred: Wistar, Long-Evans, Spraque Dawley, etc.

• Freedom to operate thanks to our unique IP portfolio, including licenses from MIT and Merck KGaA
• Rigorous off-target assessment

Basically, two models are very common:

• Point mutation KI
  One or more mutated nucleotides causing gain or loss of function of a given protein

• Quick Knockin
  Controlled gene expression/copy number by targeting the permissive (neutral) locus Rosa26

‍