Knockout cell lines

A constitutive Knockout cell line, also referred to as conventional Knockout (KO), defines a model in which the target gene is permanently inactivated.

No protein is produced.

Applications

For academic research:

• Determine and study main functions of the gene and/or protein
• Loss-of-gene-function studies‍
• In vitro recapitulation of a human disease

For bio-pharmaceutical research & development:

• In vitro target validation
• Mimic human disease for drug studies and screenings
• Positive control for antagonist drug screening
• Synthetic lethality screening
• Study safety, specificity, and off-target activity of drug candidates
• Improve performance of bioproduction models