Knockout rat models

A gene Knockout (KO) rat defines a model in which, by means of gene targeting, one or more genes of interest are disrupted or inactivated.

Since 2002, we have been heavily investing in rat model development (see our history), and have designed a unique CRISPR/Cas9-based offer, combining our:

• Expertise in model design
• Rigorous quality controls for rat models

With the advantages of gene CRISPR/Cas9 technology, such as:

• Cost effectiveness
• Short development time

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Your benefits and guarantees:

• Robust design for physiological relevant rat models
• Reliable and reproducible performance in many rat strains, including, but not limited to:
• Inbred: Brown Norway, Fischer 344, Lewis, etc.
• Outbred: Wistar, Long-Evans, Spraque Dawley, etc.

• Freedom to operate thanks to our unique IP portfolio, including licenses from MIT and Merck KGaA
• Rigorous off-target assessment

Basically, two approaches are very common:

• Constitutive (also called conventional or whole-body) KOs
  Permanent inactivation of the target gene, and total absence of the protein in the whole animal, in every cell of the organism

• Conditional (tissue-specific or time-dependent) KOs
  Spatial (in specific tissue or cell types) or temporal (at a given time-point in embryonic, post-natal or adult animals) inactivation of the target gene