Christensen PKF et al. | 2023, February 17 | LEO Pharma
https://pubmed.ncbi.nlm.nih.gov/36800344/
Research summary
This study examines the effect of imiquimod (IMQ) on skin inflammation in humanized genO-BRGSF mice boosted with human Flt3L. Although skin inflammation and epidermal thickening occurred, the response was mainly mediated by murine immune cells, with limited human immune cell activation.
Key outcome of the study
IMQ treatment induced skin inflammation characterized by epidermal thickening and immune cell infiltration. However, human immune cell activity remained limited, with the inflammatory response largely driven by the murine immune system.
Mouse model generated by genOway
genO-BRGSF-HIS humanized mouse model developed by genOway, reconstituted with human CD34+ hematopoietic stem cells and boosted with human Flt3L to support human immune system engraftment.
Imiquimod induces skin inflammation in humanized BRGSF mice with limited human immune cell activity
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