Quick Knockin mouse

Applications

For academic research:

• Gene function studies by overexpression if Knockout has no or little phenotype
• Rescue experiment to validate specificity of the Knockout phenotype
• Protein structure and function studies
• Expression pattern analysis
• Expression of specific isoform to decipher its particular function
• Express human gene that has no mouse orthologue
• Model of dominant negative or gain-of-function mutation of human disease

For bio-pharmaceutical research & development:

• Validate drug candidate by expression of mutant form of receptor mimicking its role
• Validate mutation in target as disease-causing agent
• Test protective effect on controlled gene expression on disease onset or progression
• Identification biomarkers in human disease model
• Get mouse model that cross-reacts with human-specific therapeutic antibody (or similar)