Cblb conditional Knockout mouse

Target

Gene symbol :

Cblb

NCBI gene ID :

208650

Gene full name :

Cbl proto-oncogene B

Synonym :

Casitas B-lineage lymphoma proto-oncogene-b

Protein function

Protein name :

CBL-B

E3 ubiquitin ligase that negatively regulates T-cell and B-cell receptor signaling.

Expected phenotype

Enhanced immune activation, autoimmunity

Human disease relevance

Linked to autoimmunity and transplant rejection

Model applications

Immune tolerance, T-cell regulation, autoimmunity

Keywords:

E3 ligase, Immune checkpoint, T-cell regulation

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
WoldWide delivery by professional breeders

Cblb

conditional Knockout mouse

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hPD-1 hLAG3

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hPD-1 hLAG3

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur.

hPD-1 hLAG3

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur.

hPD-1 hLAG3

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur.