Cblb conditional Knockout mouse

Target

Gene symbol :

Cblb

NCBI gene ID :

208650

Gene full name :

Cbl proto-oncogene B

Synonym :

Casitas B-lineage lymphoma proto-oncogene-b

Protein function

Protein name :

CBL-B

E3 ubiquitin ligase that negatively regulates T-cell and B-cell receptor signaling.

Expected phenotype

Enhanced immune activation, autoimmunity

Human disease relevance

Linked to autoimmunity and transplant rejection

Model applications

Immune tolerance, T-cell regulation, autoimmunity

Keywords:

E3 ligase, Immune checkpoint, T-cell regulation

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Cblb

conditional Knockout mouse

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