Knockout and reporter models

Our off-the-shelf Knockout & reporter models are well established, validated and widely used mouse and rat lines.

Knockout models

Knockout models, a cornerstone in biomedical research, involve the targeted inactivation of specific genes to understand their function. By "knocking out" a gene, you can observe the resulting phenotype changes, shedding light on the gene's role in health and disease.

Platforms like EUCOMM (European Conditional Mouse Mutagenesis Program) contribute significantly, providing a standardized approach to generating and studying Knockout mice. These models are instrumental in deciphering gene functions, offering crucial insights into molecular pathways and potential therapeutic targets.

Reporter models

Reporter models are genetically modified with reporter genes, like fluorescent proteins, to enable real-time visualization of specific biological processes.

They serve as invaluable tools for researchers, providing dynamic insights into disease progression, treatment responses, and the effects of genetic modifications.

By observing the behavior of reporter genes in living animals, scientists gain a deeper understanding of complex biological mechanisms, making these models indispensable in advancing biomedical research.


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Knockout and reporter models

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Model Eucomm

>2000 conditional Knockout mouse models for target discovery and  confirmation, in vivo compound specificity, MOA, and clinical studies

Eucomm

IL-4-IRES-eGFP

The reliable monitoring and sorting of IL-4-secreting cells allows you to efficiently delineate the immune response polarization toward the Th2 pathway.

Mouse
Reporter
IL-4

Foxp3-IRES-mRFP

This reliable Foxp3 reporter mouse allows you to efficiently monitor/sort Foxp3-expressing cells from different lymphocyte lineages & lymphoid organs

Mouse
Reporter
Foxp3

HSA/hFcRn-Rag1-KO

This upgraded, immunocompromised Rag1-/- version of our HSA/hFcRn mouse model allows the assessment of compounds' half-life and anti-tumor efficacy in a human tumor model.

Mouse
HSA
PK/PD
Immunodeficient

GFP rat

The GFP rat is suitable for organ & tissue transplantations and used in many biomedical fields (development, toxicology, orthotopic transplantation).

Rats
Reporter
GFP

Btk rat

Btk Knockout rat to study B-cell malignancies, aberrant B-cell responses, Btk inhibitors for treatments of hematologic cancers or autoimmune diseases.

Rats
Immunodeficient
Knockout
BTK

hGITR/Foxp3

The hGITR/Foxp3 mouse enables the in vivo efficacy assessment and profiling of immuno-oncology agents targeting the human immune checkpoint GITR. The red fluorescent protein regulated under the Foxp3 promoter allows you to efficiently monitor and sort Foxp3-expressing cells from different lymphocyte lineages and lymphoid organs.

Mouse
ICP
Reporter
GITR
Foxp3

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