Dhodh conditional Knockout mouse

Target

Gene symbol :

Dhodh

NCBI gene ID :

56749

Gene full name :

Dihydroorotate dehydrogenase (quinone), mitochondrial

Synonym :

DHOdehase, DHOdehyd

Protein function

Protein name :

Dihydroorotate dehydrogenase

Catalyzes a key step in de novo pyrimidine synthesis

Expected phenotype

Impaired cell proliferation, mitochondrial dysfunction

Human disease relevance

Target in autoimmune and cancer therapy

Model applications

Pyrimidine metabolism, immunology, cancer models

Keywords:

Pyrimidine, Metabolism, Drug target

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Dhodh

conditional Knockout mouse

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