Eif2b3 conditional Knockout mouse

Target

Gene symbol :

Eif2b3

NCBI gene ID :

108067

Gene full name :

Eukaryotic translation initiation factor 2B, subunit 3 gamma

Synonym :

Eif-2b

Protein function

Protein name :

eIF2B subunit gamma

Catalyzes GDP–GTP exchange on eIF2; essential for translation initiation

Expected phenotype

Mutations cause impaired protein synthesis and developmental delay

Human disease relevance

Linked to leukodystrophies such as Vanishing White Matter disease

Model applications

Used in translation regulation and neurodegeneration studies

Keywords:

Translation initiation, eIF2B complex, Protein synthesis, Leukodystrophy

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Eif2b3

conditional Knockout mouse

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