Elac2 conditional Knockout mouse

Target

Gene symbol :

Elac2

NCBI gene ID :

68626

Gene full name :

ElaC ribonuclease Z 2

Synonym :

ElaC2, Zrfg1

Protein function

Protein name :

Zinc phosphodiesterase ELAC protein 2

Processes tRNA 3' ends; involved in mitochondrial tRNA maturation and respiratory function

Expected phenotype

Knockout results in mitochondrial dysfunction and embryonic lethality

Human disease relevance

Associated with prostate cancer and mitochondrial disorders

Model applications

Used in studies of tRNA processing and mitochondrial diseases

Keywords:

tRNA processing, Mitochondria, Cancer, RNA maturation

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Elac2

conditional Knockout mouse

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