Fgd4 conditional Knockout mouse

Target

Gene symbol :

Fgd4

NCBI gene ID :

224014

Gene full name :

FYVE, RhoGEF and PH domain containing 4

Synonym :

Frabin

Protein function

Protein name :

Rho guanine nucleotide exchange factor FGD4

Activates CDC42, regulating actin cytoskeleton and Schwann cell function

Expected phenotype

KO models show peripheral neuropathy

Human disease relevance

Mutations cause Charcot-Marie-Tooth disease type 4H

Model applications

Studied in peripheral nerve development and neuropathies

Keywords:

CDC42, RhoGEF, Actin remodeling, Neuropathy

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Fgd4

conditional Knockout mouse

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Models with certified health status from professional breeders in US and Europe