Hdac8 conditional Knockout mouse

Target

Gene symbol :

Hdac8

NCBI gene ID :

70315

Gene full name :

Histone deacetylase 8

Synonym :

Histone deacetylase 8

Protein function

Protein name :

Histone deacetylase 8

Removes acetyl groups from histones; regulates gene expression and cohesion complex

Expected phenotype

Knockout mice have craniofacial defects and reduced viability

Human disease relevance

Mutations cause Cornelia de Lange syndrome-like phenotypes

Model applications

Model for chromatin regulation and developmental syndromes

Keywords:

Epigenetics, Chromatin, Cohesin, Development

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Hdac8

conditional Knockout mouse

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