Hecw1 conditional Knockout mouse

Target

Gene symbol :

Hecw1

NCBI gene ID :

94253

Gene full name :

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1

Synonym :

NEDL1

Protein function

Protein name :

E3 ubiquitin-protein ligase HECW1

E3 ligase involved in p53 regulation and neuronal development

Expected phenotype

Knockouts show neurodevelopmental and motor coordination deficits

Human disease relevance

Implicated in ALS and neurodevelopmental syndromes

Model applications

Used in studies of ubiquitination, neural development, and motor disorders

Keywords:

E3 ligase, Ubiquitin, p53 pathway, Neurodevelopment

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Hecw1

conditional Knockout mouse

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