Optn conditional Knockout mouse

Target

Gene symbol :

Optn

NCBI gene ID :

71648

Gene full name :

Optineurin

Synonym :

FIP2, NRP

Protein function

Protein name :

Optineurin

Involved in autophagy, vesicle trafficking, and NF-κB regulation

Expected phenotype

Knockouts show progressive retinal degeneration and neuroinflammation

Human disease relevance

Linked to glaucoma, ALS, and Paget disease of bone

Model applications

Used in neurodegeneration, autophagy, and inflammation research

Keywords:

Autophagy, Glaucoma, ALS, Vesicle trafficking, NF-κB

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Optn

conditional Knockout mouse

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Models with certified health status from professional breeders in US and Europe