Spg20 conditional Knockout mouse

Target

Gene symbol :

Spg20

NCBI gene ID :

229285

Gene full name :

Spastic paraplegia 20 (Troyer syndrome)

Synonym :

Spartin

Protein function

Protein name :

Spartin

Involved in endosomal trafficking and mitochondrial maintenance

Expected phenotype

KO mice show motor dysfunction and axonal degeneration

Human disease relevance

Mutations cause Troyer syndrome (hereditary spastic paraplegia)

Model applications

Model for motor neuron degeneration and mitochondrial disease

Keywords:

Axonopathy, Endosomal trafficking, Troyer syndrome, Neurodegeneration

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Spg20

conditional Knockout mouse

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