Target

Gene symbol :  
Tardbp
NCBI gene ID :  
230908
Gene full name :  
TAR DNA-binding protein 43
Synonym :  
TDP-43

Protein function

Protein name :  
TAR DNA-binding protein 43
RNA/DNA-binding protein involved in splicing, transport, and stability of mRNA

Expected phenotype

KO is embryonic lethal; heterozygotes show motor neuron degeneration

Human disease relevance

Mutations linked to ALS and frontotemporal dementia

Model applications

Used in neurodegeneration and RNA processing studies

Keywords:

RNA splicing, ALS, Neurodegeneration, TDP-43

Availability & Delivery:

  • Cryo-recovery using in-house SOPF facilities
  • Worldwide delivery by professional breeders

Tardbp

conditional Knockout mouse

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