Apelin expression deficiency in mice contributes to vascular stiffening by extracellular matrix remodeling of the aortic wall

Romier B
University of Reims Champagne-Ardenne
January 1, 2021
Cell Rep
https://pubmed.ncbi.nlm.nih.gov/34782679

This article is currently being updated. View its version on PubMed.

https://pubmed.ncbi.nlm.nih.gov/34782679

Research summary

Apelin-deficient (APL‑KO) mice develop increased aortic stiffness and hypertension through extracellular matrix remodeling. Deficiency alters adipose tissue secretome, elevates protease (cathepsin S, neutrophil elastase) activity, leading to collagen (type I/III) accumulation and elastic fiber fragmentation in the aortic wall, raising pulse wave velocity (PWV) and mean arterial pressure.

Key outcome of the study

Apelin loss causes adipose inflammation; ECM remodeling in aorta (collagen deposition, elastolysis); elevated PWV and systemic hypertension; increased cathepsin S activity mediates elastic fiber fragmentation

Model

Apelin Knockout mouse (Apelin⁻/⁻) — genOway‑developed, C57BL/6 background

TARGET:
Apln
Synonyms:
Apel

Keywords

Vascular stiffening; arterial hypertension; ECM remodeling; adipokine role; obesity-linked vascular pathology

Technical specifications

Homologous recombination targeting Apln in ES cells; Apelin^–/– constitutive Knockout; phenotyping via PWV, blood pressure tail cuff; histological collagen/elastin assays; adipose secretome protease activity

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