This study investigates the role of monocarboxylate transporter 1 (MCT1) in CD8⁺ T cell function during obesity-induced inflammation. Using a T cell-specific Slc16a1 (MCT1) Knockout mouse model, researchers found that MCT1 deficiency impairs CD8⁺ T cell proliferation and alters their metabolic programming, leading to reduced recruitment to adipose tissue and decreased adipose tissue inflammation during high-fat diet-induced obesity.
MCT1 deficiency in T cells impairs CD8⁺ T cell proliferation and recruitment to adipose tissue, leading to reduced adipose tissue inflammation during obesity.
T cell-specific Slc16a1 (MCT1) conditional Knockout mouse model (Slc16a1^flox/flox; CD4-Cre), developed to study the impact of MCT1 deficiency in T cells during obesity.
Obesity, T cell metabolism, Adipose tissue inflammation, Immunometabolism
Conditional Knockout, CD4-Cre, T cell-specific gene deletion, Metabolic reprogramming
From model design to experimental results
Tailor-made solutions adapted to scientific questions
Comprehensive dataset package
Generated with biopharma partners and in-house
Scientific follow-up and advice along the project
Collaborative approach for problem solving and development of innovative models
Breeding facilities in US and Europe
Certified health status from professional breeders
