This study demonstrates that Prdm12 is essential for the development of nociceptive sensory neurons by regulating the expression of the nerve growth factor receptor TrkA. Using a Prdm12 conditional Knockout mouse model, the authors show that loss of Prdm12 leads to a significant reduction in TrkA expression, resulting in impaired nociceptor development and function. The findings highlight the critical role of Prdm12 in pain perception pathways.
Prdm12 is crucial for initiating and maintaining TrkA expression in developing nociceptors; its absence leads to defective pain-sensing neuron development.
Prdm12 conditional Knockout mouse model generated by genOway, with targeted deletion of Prdm12 in sensory neurons to study its role in nociceptor development.
Nociceptor development, Pain perception, NGF signaling, TrkA expression
Conditional Knockout, Sensory neuron-specific deletion, Prdm12 gene targeting
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