This study identifies VISTA as a distinct negative checkpoint regulator on naïve T cells, crucial for maintaining immune quiescence and self-tolerance. Using both VISTA Knockout and humanized VISTA Knockin mouse models, the authors demonstrated that loss of VISTA disrupts naïve T cell homeostasis and enhances self-reactivity. Agonistic targeting of VISTA promoted peripheral deletion of autoreactive T cells and immune tolerance.
VISTA promotes naïve T cell quiescence and peripheral tolerance. Humanized VISTA models confirm conserved function and relevance to therapeutic checkpoint modulation.
Humanized VISTA Knockin mouse model developed by genOway (alongside VISTA Knockout), expressing human VSIR to evaluate tolerance and quiescence in vivo.
T cell tolerance, Autoimmunity, Immune checkpoints, Naïve T cells, VISTA targeting
Humanized Knockin model, VISTA gene replacement, Vsir Knockout
From model design to experimental results
Tailor-made solutions adapted to scientific questions
Comprehensive dataset package
Generated with biopharma partners and in-house
Scientific follow-up and advice along the project
Collaborative approach for problem solving and development of innovative models
Breeding facilities in US and Europe
Certified health status from professional breeders
