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PET-based immunomapping of intratumoral CD4+ cells to monitor acquired resistance to checkpoint inhibitors

Sci Adv

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Scientific articles

The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation.

Exp Neurol

The epigenetic regulator PLZF represses L1 retrotransposition in germ and progenitor cells.

EMBO J

Role of the ectonucleotidase NTPDase2 in taste bud function

Proc Natl Acad Sci U S A

Role of Helicase-Like Transcription Factor (Hltf) in the G2/M Transition and Apoptosis in Brain

PLoS One

Platelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in mice

Blood

Perilipin-2 Null Mice are Protected Against Diet-Induced Obesity, Adipose Inflammation and Fatty Liver Disease.

J Lipid Res

Neuronal Expression of Soluble Adenylyl Cyclase in the Mammalian Brain.

Brain Res

Nck Recruitment to the TCR Required for ZAP70 Activation during Thymic Development.

J Immunol

Muscle glycogen synthase isoform is responsible for testicular glycogen synthesis: Glycogen overproduction induces apoptosis in male germ cells.

J Cell Biochem

Limited regeneration in long acellular nerve allografts is associated with increased Schwann cell senescence.

Exp Neurol

JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis

J Biol Chem

Increased activity of mitogen activated protein kinase pathway in flotillin-2 knockout mouse model

Cellular Signalling

Impact of inhibitory constraint of interneurons on neuronal excitability

J Neurophysiol

Heat Shock Protein B1-Deficient Mice Display Impaired Wound Healing

PLoS One

Generation of Rag1-knockout immunodeficient rats and mice using engineered meganucleases.

FASEB J

Establishing a novel knock-in mouse line for studying neuronal cytoplasmic dynein under normal and pathologic conditions.

Cytoskeleton

Extracellular protein disulfide isomerase regulates ligand-binding activity of αMβ2 integrin and neutrophil recruitment during vascular inflammation

Blood

Downregulation of FOXP1 is required during germinal center B-cell function.

Blood

Detection of Intracellular Factor VIII Protein in Peripheral Blood Mononuclear Cells by Flow Cytometry

BioMed Research International

Comparative gene expression profiling of adult mouse ovary-derived oogonial stem cells supports a distinct cellular identity

Fertil Steril

Characterization of Acid sphingomyelinase activity in human cerebrospinal fluid.

PLoS One

CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes.

Nature

Behavioural and functional characterization of Kv10.1 (Eag1) knockout mice.

Hum Mol Genet

ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility

Mol Cell

ALKBH4-dependent demethylation of actin regulates actomyosin dynamics

Nat Commun

The human OPA1delTTAG mutation induces premature age-related systemic neurodegeneration in mouse.

Brain

Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses.

Cell

Peripheral injections of melanin-concentrating hormone receptor 1 antagonist S38151 decrease food intake and body weight in rodent obesity models

Front Endocrinol (Lausanne)

Mice deficient in hepatocyte-specific IL-1Ra show delayed resolution of concanavalin A-induced hepatitis.

Eur J Immunol

Mice Genetically Depleted of Brain Serotonin Display Social Impairments, Communication Deficits and Repetitive Behaviors: Possible Relevance to Autism

PLoS One

Loss of the tumor suppressor BAP1 causes myeloid transformation.

Science

Knock-in mice for the R50X mutation in the PYGM gene present with McArdle disease

Brain

Functional Significance of SRJ Domain Mutations in CITED2.

PLoS One

Genetic depletion of brain 5HT reveals a common molecular pathway mediating compulsivity and impulsivity

J Neurochem

Deleterious effects of neuronal accumulation of glycogen in flies and mice

EMBO Molecular Medicine

Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2

Nature (Letter)

The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia

Hum Mol Genet

The F-BAR protein NOSTRIN participates in FGF signal transduction and vascular development.

EMBO J

The Glucocorticoid-Induced Leucine Zipper (Gilz/Tsc22d3-2) Gene Locus Plays a Crucial Role in Male Fertility.

Mol Endocrinol

Targeted knockdown of Cerkl, a retinal dystrophy gene, causes mild affectation of the retinal ganglion cell layer

Biochim Biophys Acta

Role of the Polarity Protein Scribble for Podocyte Differentiation and Maintenance

PLoS One

Restricted expression of Neuroglobin in the mouse retina and co-localization with Melanopsin and Tyrosine Hydroxylase

Biochem Biophys Res Commun

Reduced infarct size in neuroglobin-null mice after experimental stroke in vivo

ETSM

P-gp substrate-induced neurotoxicity in an Abcb1a knock-in/Abcb1b knock-out mouse model with a mutated canine ABCB1 targeted insertion.

Res Vet Sci

Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice.

Diabetes

Neurotoxic effects of ivermectin administration in genetically engineered mice with targeted insertion of the mutated canine ABCB1 gene

Am J Vet Res

MCM8- and MCM9 -Deficient Mice Reveal Gametogenesis Defects and Genome Instability Due to Impaired Homologous Recombination

Mol Cell Biol

Mesenchymal stem cell therapy prevents IFTA in a rat kidney allograft model

Stem Cells Dev

Mammary gland development is delayed in mice deficient for aminopeptidase N

Transgenic Res

Lysosomal dysfunction causes neurodegeneration in mucolipidosis II 'knock-in' mice.

Brain

Knockout of the prion protein (PrP)-like Sprn gene does not produce embryonic lethality in combination with PrPC-deficiency

Proc Natl Acad Sci U S A

Geldanamycin accelerated peripheral nerve regeneration in comparison to FK-506 in vivo.

Neuroscience

GABAergic Inhibition of Histaminergic Neurons Regulates Active Waking But Not the Sleep–Wake Switch or Propofol-Induced Loss of Consciousness

J Neurosci

Flower-deficient mice have reduced susceptibility to skin papilloma formation

Dis Model Mech

EPAC Null Mutation Impairs Learning and Social Interactions via Aberrant Regulation of miR-124 and Zif268 Translation

Neuron

Effects of high-fat diet feeding on Znt8-null mice: differences between β-cell and global knockout of Znt8.

Am J Physiol Endocrinol Metab

Disruption of the histidine triad nucleotide‐binding hint2 gene in mice affects glycemic control and mitochondrial function

Hepatology

Circadian Behaviour in Neuroglobin Deficient Mice

PLoS One

Cellular heterogeneity during embryonic stem cell differentiation to epiblast stem cells is revealed by the ShcD/RaLP adaptor protein.

Stem Cells

Cellular ageing, increased mortality and FTLD‐TDP‐associated neuropathology in progranulin knockout mice

J Pathol

Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability.

Proc Natl Acad Sci U S A

Bone Marrow-Derived IL-13Rα1–Positive Thymic Progenitors Are Restricted to the Myeloid Lineage

J Immunol

C3G transgenic mouse models with specific expression in platelets reveal a new role for C3G in platelet clotting through its GEF activity

Biochim Biophys Acta

ATXN2-CAG42 Sequesters PABPC1 into Insolubility and Induces FBXW8 in Cerebellum of Old Ataxic Knock-In Mice

PloS Genetics

Acceleration of collateral development by carcinoembryonic antigen-related cell adhesion molecule 1 expression on CD11b/⁺Gr-1⁺ myeloid cells--brief report

Arterioscler Thromb Vasc Biol

Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice.

Diabetologia

A transgenic rat expressing green fluorescent protein (GFP) in peripheral nerves provides a new hindlimb model for the study of nerve injury and regeneration

J Neurosci Methods

In vitro modelling of Alzheimer's disease: Degeneration and cell death induced by viral delivery of amyloid and tau

Exp Neurol

Comparison of the function of the serotonin transporter in the vasculature of male and female rats

Clin Exp Pharmacol Physiol

Abnormal Cognition Sleep EEG and Brain Metabolism in a Novel Knock-In Alzheimer Mouse PLB1.

PLoS One

Synaptotagmin10-Cre, a driver to disrupt clock genes in the SCN.

J Biol Rhythms

Serotonin transporter interacts with the PDGFβ receptor in PDGF-BB-induced signaling and mitogenesis in pulmonary artery smooth muscle cells

Am J Physiol Lung Cell Mol Physiol

Pharmacological blockade or genetic knockout of the NOP receptor potentiates the rewarding effect of morphine in rats.

Drug Alcohol Depend

Nociceptin/orphanin FQ receptor knockout rats: in vitro and in vivo studies.

Neuropharmacology

Neuroglobin-Deficiency Exacerbates Hif1A and c-FOS Response, but Does Not Affect Neuronal Survival during Severe Hypoxia In Vivo

PLoS One

Milk Lacking α-Casein Leads to Permanent Reduction in Body Size in Mice

PLoS One

Lack of the serotonin transporter (SERT) reduces the ability of 5-hydroxytryptamine to lower blood pressure.

Naunyn Schmiedebergs Arch Pharmacol

Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet

Proc Natl Acad Sci U S A

Glutaminyl Cyclase Knock-out Mice Exhibit Slight Hypothyroidism but No Hypogonadism: IMPLICATIONS FOR ENZYME FUNCTION AND DRUG DEVELOPMENT.

J Biol Chem

Genetic Deletion of Trace Amine 1 Receptors Reveals Their Role in Auto-Inhibiting the Actions of Ecstasy (MDMA)

J Neurosci

Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia

Proc Natl Acad Sci U S A

Effects of Human Alpha-Synuclein A53T-A30P Mutations on SVZ and Local Olfactory Bulb Cell Proliferation in a Transgenic Rat Model of Parkinson Disease

Parkinsons Dis

Drug targeting to monocytes and macrophages using esterase-sensitive chemical motifs.

J Pharmacol Exp Ther

Deletion of the dual specific phosphatase-4 (DUSP-4) gene reveals an essential non-redundant role for MAP kinase phosphatase-2 (MKP-2) in proliferation and cell survival

J Biol Chem

Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema.

Proc Natl Acad Sci U S A

Cohesin acetyltransferase Esco2 is a cell viability factor and is required for cohesion in pericentric heterochromatin.

EMBO J

Characterisation of a C1qtnf5 Ser163Arg Knock-In Mouse Model of Late-Onset Retinal Macular Degeneration.

PLoS One

CCN2 is required for bleomycin-induced skin fibrosis in mice.

Arthritis Rheum

CCN2 is not required for skin development

J Cell Comm Signal

BRCA1 RING Function Is Essential for Tumor Suppression but Dispensable for Therapy Resistance

Cancer Cell

ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA

Nat Commun

A point mutation in the ubiquitin-associated domain of SQSMT1 is sufficient to cause a Paget's disease-like disorder in mice.

Hum Mol Genet

A role for the peroxisomal 3-ketoacyl-CoA thiolase B enzyme in the control of PPARα-mediated upregulation of SREBP-2 target genes in the liver

Biochimie

Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate abeta formation, induces behavioral deficits and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice.

J Biol Chem

MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana.

PLoS Pathog

Enhanced Th1 and Th17 Responses and Arthritis Severit y in Mice With a Deficiency of Myeloid Cell–Specific Interleukin-1 Receptor Antagonist

Arthritis Rheum

Distinct Roles of Hepatocyte- and Myeloid Cell-Derived IL-1 Receptor Antagonist during Endotoxemia and Sterile Inflammation in Mice.

J Immunol

Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo.

Diabetologia

Trace amines depress D2-autoreceptor-mediated responses on midbrain dopaminergic cells

Br J Pharmacol

The ubiquitin ligase MYCBP2 regulates transient receptor potential vanilloid receptor 1 (TRPV1)-internalization through inhibition of p38 MAPK signaling.

J Biol Chem

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