Scientific articles of research breakthroughs | genOway

C92, a proton channel-blocking allosteric STING agonist generates robust antitumor activity

Journal for ImmunoTherapy of Cancer

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Scientific articles

C92, a proton channel-blocking allosteric STING agonist generates robust antitumor activity

Journal for ImmunoTherapy of Cancer

First-in-human study of lomvastomig, a PD-1-TIM-3 bispecific antibody, in patients with advanced and/or metastatic solid tumors

J Immunother Cancer

Tobemstomig, a novel bispecific antibody, preferentially blocks PD-1 and LAG-3 on CD8 TILs to expand stem-like T-cells for sustained tumor control

Cancer Res Commun

Cell-specific Y-box binding protein-1 drives liver-kidney injury in cholestasis

Am J Physiol Renal Physiol

Astro-Versus Microglia-Enriched Transcriptomes from Aged Atxn2-CAG100-Knockin Mice Suggest Underlying Pathology of RNA Processing at Ribosomes, and Possibly at U-Bodies

Cells

Pharmacological PIK3C2B inhibition rescues XLMTM phenotype in mouse models and identifies molecular markers of disease

JCI Insight

Spontaneous clinical and anatomical pathology findings in SDRG rats

Vet Pathol

Intestinal epithelial Smad7 drives purine metabolic dysregulation and ileal inflammation

J Biomed Sci

DEL-1 is an Endogenous Senolytic Protein that Inhibits Senescence-Associated Bone Loss

Adv Sci (Weinh)

Cross-species cellular mapping and humanization of Fcγ receptors to advance antibody modeling

Sci Immunol

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Reversing enhancer RNA–mediated IKBKE gene repression enables synthetic anticancer immunity in prostate cancer models

J Clin Invest

Efzimfotase Alfa Improves Respiratory Capacity in Muscle Tissue From a Mouse Model of HPP

JIMD Rep

cGAS-STING signaling in the tumor microenvironment induces myeloid cell activation and favors T cell-mediated antitumor immunity

Cancer Biol Ther

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A homozygous variant in the beta‑1,3‑N‑acetylglucosaminyltransferase 4 gene causes progressive brain atrophy and muscular dystrophy

Eur J Hum Genet

Loss of C9orf72 impacts the peripheral neuromuscular system via immune dysregulation and accelerates the progression of amyotrophic lateral sclerosis in SOD‑1 mutant mice

J Neuroinflammation

Additive Effects of Dorzagliatin and Glucagon-Like Peptide-1 Receptor Agonism in a Novel Mouse Model of GCK-MODY and in Obese db/db Mice

Diabetes

Characterization of human lung immune cells in the humanized BRGSF mouse model

J Immunol

Conditional Atxn2l deletion caused hypoactivity without cell loss and altered expression of splicing-related proteins, supporting a role for ATXN2L in RNA regulation in mature neurons

Cells

Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models

Nat Commun

Tissue Distribution and Phenotype of Human Mast Cells in BRGSF and NSG-SGM3-IL15 Humanized Mice

Allergy

 Conditionally Active CD28xVISTA Bispecific Antibodies Promote Myeloid‑Driven T‑Cell Activation

Cancer Immunol Res

Tumor-dependent myeloid and lymphoid cell recruitment in genO-BRGSF-HIS mice: a novel tool for evaluating immune therapies

Front Immunol

Talin autoinhibition is required for normal hemostasis

Platelets

Loss of M1 Acetylcholine Receptor-mediated Orexinergic Activity Contributes to Immune Dysfunction in Experimental Sepsis

Res Sq

Intracrine FFA4 signaling controls lipolysis at lipid droplets

Nat Chem Biol

An affinity-modulated T cell engager targeting Claudin 18.2 shows potent anti-tumor activity with limited cytokine release

J Immunother Cancer

Advancing In Vivo Detection of T‑Cell Function: Development and Preclinical Evaluation of ⁸⁹Zr‑Ivuxolimab, a Human OX40 PET Tracer

J Nucl Med

Analysis of Fc-dependent effector functions of anti-malaria circumsporozoite protein antibodies

Microbiol Spectr

ANV600 is a novel PD-1 targeted IL-2Rβγ agonist that selectively expands tumor antigen-specific T cells and potentiates PD-1 checkpoint inhibitor therapy

J Immunother Cancer

Exploiting FcRn engagement of an albumin-CpG oligonucleotide covalent conjugate for potent TLR9 immune induction

J Biol Chem

PET-based immunomapping of intratumoral CD4+ cells to monitor acquired resistance to checkpoint inhibitors

Sci Adv

Consolidation of cell‑ECM adhesion through direct talin‑mediated actin linkage is essential for mouse embryonic morphogenesis

Commun Biol

Sonic hedgehog medulloblastomas are dependent on Netrin-1 for survival

Nat Commun

DEPDC5 regulates the strength of excitatory synaptic transmission by interacting with ubiquitin-specific protease 46

Neurobiol Dis

Anti-pyroglutamate-3 Aβ immunotherapy engages microglia and inhibits amyloid accumulation in transgenic mouse models of Aβ amyloidosis

Acta Neuropathol

IGM-7354, an immunocytokine with IL-15 fused to an anti-PD-L1 IgM, induces NK and CD8+ T cell-mediated cytotoxicity of PD-L1 positive tumor cells

Cancer Immunol Res

Gonadotrophs have a dual origin, with most derived from early postnatal pituitary stem cells

Nat Commun

A Novel B7-H4xCD3 Bispecific T Cell Engager (PF-07260437) Synergizes with Breast Cancer Standard of Care and Immune-Checkpoint Therapies

Mol Cancer Ther

Reannotation of cancer mutations based on expressed RNA transcripts reveals functional non-coding mutations in melanoma

Am J Hum Genet

Non-canonical Wnt signaling promotes epithelial fluidization in the repairing airway

Nat Commun

An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse models

Nat Commun

Reactivation of CTLA4-expressing T cells Accelerates Resolution of Lung Fibrosis in a Humanized Mouse Model

J Clin Invest

Evolutionary fingerprints of epithelial-to-mesenchymal transition

Nature

An inducible FOXL2-dependent mouse model of ovarian adult type granulosa cell tumor

Gynecol Oncol

Translational error in mice increases with ageing in an organ-dependent manner

Nat Commun

Implications of tissue specific STING protein flux and abundance on inflammation and the development of targeted therapeutics

PLoS One

Loss of the neuronal kinase DCLK3 leads to anxiety-like behaviour and memory deficits

Brain

The ABC transporter A7 modulates neuroinflammation via NLRP3 inflammasome in Alzheimer’s disease mice

Alzheimers Res Ther

EBP1 potentiates amyloid β pathology by regulating γ-secretase

Nat Aging

NI-3201 Is a Bispecific Antibody Mediating PD-L1-Dependent CD28 Co-stimulation on T Cells for Enhanced Tumor Control

Cancer Immunol Res

Brainstem BDNF neurons are downstream of GFRAL/GLP1R signalling

Nat Commun

GalNT2-mediated O-glycosylation affects pancreas development and function in mice

Sci Rep

NK2R control of energy expenditure and feeding to treat metabolic diseases

Nature

PAR2 on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451

Biomaterials

Neuromedin U Neurons in the Edinger-Westphal Nucleus Respond to Alcohol Without Interfering with the Urocortin 1 Response

Neurochem Res

Generation and Characterization of a Novel Prkcd‑Cre Rat Model

J Neurosci

Efficient generation of human immune system rats using human CD34+ cells

Stem Cell Reports

In-depth cross-validation of human and mouse CD4-specific minibodies for noninvasive PET imaging of CD4+ cells and response prediction to cancer immunotherapy

Theranostics

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Targeting of immune checkpoint regulator V-domain Ig suppressor of T-cell activation (VISTA) with 89Zr-labelled CI-8993

Eur J Nucl Med Mol Imaging

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Maternal α-casein deficiency extends the lifespan of offspring and programmes their body composition

Geroscience

Conditional Knockouts of Interphotoreceptor Retinoid Binding Protein Suggest Two Independent Mechanisms for Retinal Degeneration and Myopia

Invest Ophthalmol Vis Sci

Female Alms1-deficient mice develop echocardiographic features of adult but not infantile Alström syndrome cardiomyopathy

Dis Model Mech

Female Alms1-deficient mice develop echocardiographic features of adult but not infantile Alström syndrome cardiomyopathy

Dis Model Mech

Mesenchymal-specific Alms1 knockout in mice recapitulates metabolic features of Alström syndrome

Mol Metab

Missense mutation (C667F) in murine β-dystroglycan causes embryonic lethality, myopathy and blood-brain barrier destabilization

Dis Model Mech

An ALK2 inhibitor, BLU-782, prevents heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva

Sci Transl Med

A novel BAG5 variant impairs the ER stress response pathway, causing dilated cardiomyopathy and arrhythmia

Sci Rep

Agonistic anti-DCIR antibody inhibits ITAM-mediated inflammatory signaling and promotes immune resolution

JCI Insight

Differential effects of FcRn antagonists on the subcellular trafficking of FcRn and albumin

JCI Insight

Aging-regulated PNUTS maintains endothelial barrier function via SEMA3B suppression

Mol Cancer Ther

Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy

Nat Neurosci

HPN328, a Trispecific T Cell-activating Protein Construct Targeting DLL3-Expressing Solid Tumors

Mol Cancer Ther

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INA03, a potent transferrin-competitive antibody-drug conjugate against CD71, for a safer acute leukemia treatment

Mol Cancer Ther

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Set7 Methyltransferase and Phenotypic Switch in Diabetic Glomerular Endothelial Cells

J Am Soc Nephrol

CB307: A Dual Targeting Costimulatory Humabody VH Therapeutic for Treating PSMA-Positive Tumors

Clin Cancer Res

Fitusiran reduces bleeding in Factor X-deficient mice

Blood

VISTA checkpoint inhibition by pH-selective antibody SNS-101 with optimized safety and pharmacokinetic profiles enhances PD-1 response

Nat Commun

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Hippocampal Pyk2 regulates specific social skills: Implications for schizophrenia

Neurobiol Dis

Common single-base insertions in the VNTR of the carboxyl ester lipase (CEL) gene are benign and also likely to arise somatically in the exocrine pancreas

Hum Mol Genet

Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult

Nat Cardiovasc Res

The proteasome modulates endocytosis specifically in glomerular cells to promote kidney filtration

Nat Commun

Bi-specific autoantigen-T cell engagers as targeted immunotherapy for autoreactive B cell depletion in autoimmune diseases

Front Immunol

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NAAA-regulated lipid signaling in monocytes controls the induction of hyperalgesic priming in mice

Nat Commun

An Engineered Mouse Model That Generates a Diverse Repertoire of Endogenous, High-Affinity Common Light Chain Antibodies

Front Immunol

Myeloid and dendritic cells enhance therapeutics-induced cytokine release syndrome features in humanized BRGSF-HIS preclinical model

Front Immunol

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The mitochondrial ATP-dependent potassium channel (mitoKATP) controls skeletal muscle structure and function

Cell Death Dis

Staphylococcus aureus Panton-Valentine Leukocidin worsens acute implant-associated osteomyelitis in humanized BRGSF mice

JBMRplus

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Rational design of a genomically humanized mouse model for dominantly inherited hearing loss, DFNA9

Hear Res

Sphingosine-1-phosphate receptor 3 regulates the transendothelial transport of HDL and LDL in opposite ways

Cardiovasc Res

Two birds with one stone: human SIRPα nanobodies for functional modulation and in vivo imaging of myeloid cells

Front Immunol

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Detecting Central Auditory Processing Disorders in Awake Mice

Brain Science

Mistranslation-associated perturbations of proteostasis do not promote accumulation of amyloid beta and plaque deposition in aged mouse brain

Cell Mol Life Sci

Biodistribution and function of coupled polymer-DNA origami nanostructures

Sci Rep

Inhibition of NADPH oxidase 2 improves cognitive abilities by modulating Aquaporin-4 after traumatic brain injury in mice

Heliyon

A highly potent anti-VISTA antibody KVA12123 - a new immune checkpoint inhibitor and a promising therapy against poorly immunogenic tumors

Front Immunol

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Single-cell mapping identifies MSI+ cells as a common origin for diverse subtypes of pancreatic cancer

Cancer Cell

Cathepsin D overexpression in the nervous system rescues lethality and Ab42 accumulation of cathepsin D systemic knockout in vivo

Acta Pharm Sin B

Widespread monoclonal IgE antibody convergence to an immunodominant, pro-anaphylactic Ara h 2 epitope in peanut allergy

J Allergy Clin Immunol

PA2G4/EBP1 ubiquitination by PRKN/PARKIN promotes mitophagy protecting neuron death in cerebral ischemia

Autophagy

Targeting STING oligomerization with small-molecule inhibitors

Proc Natl Acad Sci U S A

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