Catalog Models for Preclinical Research

Humanized Immune Checkpoint (ICP)
Mouse Models

Humanized immunocompetent mice harboring single or double ICP target(s); suitable to study:

  • Well-calibrated syngeneic tumor models
  • Long-term treatment(s)
  • T cell exhaustion and reminiscence
 

Immunodeficient Mouse Models

Unique preclinical models, BRGSF and BRGSF-HIS to study:

  • Vaccine and drug screening
  • Immuno-oncology
  • Infectiology
  • Personalized medicine

Repository of Knockout Mouse Models

More than 2000 ready-to-use Knockout models for:

  • Disease models
  • Target discovery and confirmation
  • In vivo compound specificity
  • Mechanism of action (MOA) studies

Double Humanized Serum Albumin / Neonatal Fc Receptor (HSA/hFcRn) Mouse Model

  • Pharmacokinetic and pharmacodynamic studies of albumin-linked drugs
  • Development of conventional drugs and biologics influenced by reversible binding to the endogenous human albumin

Humanized Mouse Models for In Vivo Immuno-Inflammatory Studies

hCD4, hTNF-α and hIgE/hFceR1 mice suitable to screen for innovative therapeutics and study:

  • Autoimmune diseases
  • Inflammation (e.g., IBD)
  • Asthma, allergies
  • Eosinophilic esophagitis

Reporter Mouse Models

IL-4-IRES-eGFP (4get) mice and Foxp3-IRES-mRFP (FIR) mice as powerful tools to study:

  • Autoimmune diseases
  • Allergies
  • HIV infection
  • Tumors

Humanized Immune Checkpoint (ICP) Cell Line Models

The MC38-hPDL1 cell line can be used for in vivo tumor growth assays in syngeneic models and in vitro mechanistic studies. Isogenic control clones are available.

GFP Reporter Rat Model

This new GFP rat strain is suitable for organ and tissue transplantation, and therefore useful for many biomedical fields, including:

  • Development
  • Toxicology
  • Orthotopic transplantation