Humanized Immune Checkpoints
Immunocompetent mice harboring single or double-humanized immune checkpoint targets; suitable to study:
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Well-calibrated syngeneic tumor models
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Long-term treatment(s)
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T cell exhaustion and reminiscence
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Immunodeficient Rodents With or Without Human Immune Systems
Preclinical mouse (BRGSF, BRGSF-A2) and rat (SDRG) models to study:
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Vaccine and drug screening
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Immuno-oncology
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Infectiology
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Personalized medicine
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Humanized CD3 Mouse Models
hCD3ε model for in vivo efficacy assessment of T-cell engagers in fully immunocompetent mice.
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Humanized Mouse Models for In Vivo Immuno-Inflammatory Studies
hCD4, hTNF-α and hIgE/hFceR1 mice suitable to screen for innovative therapeutics and study:
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Autoimmune diseases
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Inflammation (e.g., IBD)
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Asthma, allergies
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Eosinophilic esophagitis
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Double-Humanized Serum Albumin / Neonatal Fc Receptor (HSA/hFcRn) Mouse Model
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Pharmacokinetic and pharmacodynamic studies of albumin-linked drugs
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Development of conventional drugs and biologics influenced by reversible binding to the endogenous human albumin
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Repository of Knockout Mouse Models
More than 2000 ready-to-use Knockout models for:
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Disease models
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Target discovery and confirmation
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In vivo compound specificity
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Mechanism of action (MOA) studies
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Reporter Mouse Models
IL-4-IRES-eGFP (4get) mice and Foxp3-IRES-mRFP (FIR) mice as powerful tools to study:
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Autoimmune diseases
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Allergies
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HIV infection
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Tumors
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Rat Models
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GFP reporter rat suitable for organ and tissue transplantation
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Btk Knockout rat to study B cell development
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Immunodeficient SDRG rat
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Humanized Immune Checkpoint Cell Lines
Humanized immune checkpoint cell lines can be used for in vivo tumor growth assays in syngeneic models and in vitro mechanistic studies.
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Knockout Immune Checkpoint Cell Lines
Immune checkpoint Knockout clones can be used for target validation and mechanistic studies.
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