Catalog Models for Preclinical Research

Humanized Immune Checkpoints

Immunocompetent mice harboring single or double humanized immune checkpoint targets; suitable to study:

  • Well-calibrated syngeneic tumor models
  • Long-term treatment(s)
  • T cell exhaustion and reminiscence
 

Immunodeficient Rodents With or Without Human Immune Systems

Preclinical mouse (BRGSF, BRGSF-A2) and rat (SDRG) models to study:

  • Vaccine and drug screening
  • Immuno-oncology
  • Infectiology
  • Personalized medicine

Humanized CD3 Mouse Models

hCD3ε model for in vivo efficacy assessment of T-cell engagers in fully immunocompetent mice.

Humanized Mouse Models for In Vivo Immuno-Inflammatory Studies

hCD4, hTNF-α and hIgE/hFceR1 mice suitable to screen for innovative therapeutics and study:

  • Autoimmune diseases
  • Inflammation (e.g., IBD)
  • Asthma, allergies
  • Eosinophilic esophagitis

Double Humanized Serum Albumin / Neonatal Fc Receptor (HSA/hFcRn) Mouse Model

  • Pharmacokinetic and pharmacodynamic studies of albumin-linked drugs
  • Development of conventional drugs and biologics influenced by reversible binding to the endogenous human albumin

Repository of Knockout Mouse Models

More than 2000 ready-to-use Knockout models for:

  • Disease models
  • Target discovery and confirmation
  • In vivo compound specificity
  • Mechanism of action (MOA) studies

Reporter Mouse Models

IL-4-IRES-eGFP (4get) mice and Foxp3-IRES-mRFP (FIR) mice as powerful tools to study:

  • Autoimmune diseases
  • Allergies
  • HIV infection
  • Tumors

Rat Models

  • GFP reporter rat suitable for organ and tissue transplantation
  • Btk Knockout rat to study B cell development
  • Immunodeficient SDRG rat

 

Humanized Immune Checkpoint Cell Lines

Humanized immune checkpoint cell lines can be used for in vivo tumor growth assays in syngeneic models and in vitro mechanistic studies.

Knockout Immune Checkpoint Cell Lines

Immune checkpoint knockout clones can be used for target validation and mechanistic studies.