Physiological relevancy of the model
Success stories clearly demonstrate that the primary success factor is the physiological relevancy of the model.
Well-designed genetically engineered models can only be obtained through a labor-intensive, science-based analysis process, which relies on three main pillars:
- Biology of the target:
Each target is different and operates on different pathways; engineering should be done accordingly
- Goal of the project:
The model use dictates the design–a model for target validation differs from a model for toxicology studies, even though ultimately the target will be inactivated
- Business constraints of the drug discovery program:
The genetically engineered model is a part of the puzzle, and it must fit
Mouse model generation
Cell line generation
genOway's approach: It's all about the right design
For each new model: (1) a thorough scientific analysis is performed (literature, in-silico tools, risk assessment, etc.), and (2) options are ranked and compared, based on the target gene biology, model use, technical feasibility, timelines, and budget.
This well-defined decision-tree process is crucial to the quality of the research model, the quality of data resulting from the use of the model, and its impact on drug discovery programs.
Success stories have been published and publicized - but costly failures exist!
See also our catalog
Explore our comprehensive catalog of preclinical models, featuring genetically modified mice, rats, and cell lines. All our models were designed and validated with the highest standards of excellence to ensure the ultimate predictability of your research.