Reporter cell lines

A reporter cell line defines a model in which fluorescent, bioluminescent proteins or biochemical tags are inserted into the genome. The reporter can replace a gene, be fused to a protein or co-express with the target gene.

It is a particularly useful model when there are no available antibodies for the target protein or when protein measurement is laborious and costly.

Typical applications for academic research:

• Gene expression monitoring
• Cellular response monitoring
• Cell labeling
• Protein trafficking
• Biochemical analysis, e.g., protein-protein interaction and immuno-precipitation

For bio-pharmaceutical research & development:

• Read out for drug screening
• In vitro sensing
• Selectivity screening
• Compound profiling