A reporter Knockin cell line defines a model in which fluorescent, bioluminescent proteins or biochemical tags are inserted into the genome. The reporter can replace a gene, be fused to a protein or co-express with the target gene.

It is a particularly useful model when there are no available antibodies for the target protein or when protein measurement is laborious and costly.


For academic research:

  • Gene expression monitoring
  • Cellular response monitoring
  • Cell labeling
  • Protein trafficking
  • Biochemical analysis, e.g., protein-protein interaction and immuno-precipitation

For bio-pharmaceutical research & development:

  • Read out for drug screening
  • In vitro sensing
  • Selectivity screening
  • Compound profiling

Strengths of reporter Knockin cell models

  • Simple and cost-effective monitoring tool of desired cellular events without using antibodies
  • Numerous technical options optimized for different scientific questions: regulation, expression, quantififcation, etc.

Limitations of reporter Knockin cell models

  • Fusing the reporter to a protein may alter protein conformation, localization and functionality
    →  Limitation can be bypassed by applying IRES co-expression technology
  • 3' UTR approaches provide only relative quantification: potential dysregulation of expression level and challenging when multiple isoforms exist
    → Must be solved by an in-depth scientific analysis and a rationale risk assessment prior to model development, all included in our project feasibility assessment

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Reporter KI cells

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Inducible Knockdown cells

Through a single genetic modification, the addition of a self-cleaving degron tag to a protein of interest allows its inducible, and reversible, degradation upon treatment.

Point mutation

Point mutation KI cells

A point mutation Knockin cell line has one or more mutated nucleotides that alter the protein amino acid sequence, changing its functions or properties.

Permissive locus

Quick KI cells

A quick Knockin cell line has a transgene inserted into permissive loci (e.g., Rosa26). The transgene overexpression is constitutively or inducibly.


Constitutive KO cells

A constitutive Knockout cell line refers to a conventional KO; a model in which the target gene is permanently inactivated, and no protein is produced.

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Reporter Knockin cell lines

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