Target

Gene symbol :  
Cdkal1
NCBI gene ID :  
68916
Gene full name :  
CDK5 regulatory subunit associated protein 1-like 1
Synonym :  
Cdk5rap1-like

Protein function

Protein name :  
tRNA methylthiotransferase CDKAL1
Catalyzes t6A37 modification in tRNA^Lys(UUU); essential for accurate translation

Expected phenotype

Impaired insulin secretion, β-cell dysfunction

Human disease relevance

Strongly associated with type 2 diabetes in humans

Model applications

Model for diabetes susceptibility and β-cell translational regulation

Keywords:

Diabetes, β-cells, Translation, tRNA modification

Availability & Delivery:

  • Cryo-recovery using in-house SOPF facilities
  • Worldwide delivery by professional breeders

Cdkal1

conditional Knockout mouse

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