Cdkal1 conditional Knockout mouse

Target

Gene symbol :

Cdkal1

NCBI gene ID :

68916

Gene full name :

CDK5 regulatory subunit associated protein 1-like 1

Synonym :

Cdk5rap1-like

Protein function

Protein name :

tRNA methylthiotransferase CDKAL1

Catalyzes t6A37 modification in tRNA^Lys(UUU); essential for accurate translation

Expected phenotype

Impaired insulin secretion, β-cell dysfunction

Human disease relevance

Strongly associated with type 2 diabetes in humans

Model applications

Model for diabetes susceptibility and β-cell translational regulation

Keywords:

Diabetes, β-cells, Translation, tRNA modification

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Cdkal1

conditional Knockout mouse

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