Target

Gene symbol :  
Cmtm6
NCBI gene ID :  
67213
Gene full name :  
CKLF-like MARVEL transmembrane domain containing 6
Synonym :  
CKLFSF6

Protein function

Protein name :  
CMTM6
Stabilizes PD-L1 on cell surface, regulating T-cell immune checkpoints.

Expected phenotype

Enhanced T-cell activation in KO models

Human disease relevance

Key target in immune checkpoint blockade therapies

Model applications

Tumor immunity, checkpoint control

Keywords:

PD-L1, T-cell regulation, Immunotherapy

Availability & Delivery:

  • Cryo-recovery using in-house SOPF facilities
  • Worldwide delivery by professional breeders

Cmtm6

conditional Knockout mouse

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