This study investigates the role of apelin, an adipokine, in modulating emotional behaviors in mice, considering age and metabolic state. Utilizing apelin Knockout (Apelin⁻/⁻) mice, researchers observed that 12-month-old Apelin⁻/⁻ mice exhibited an antidepressant-like phenotype under standard diet conditions. Conversely, 6-month-old Apelin⁻/⁻ mice on a high-fat diet displayed increased anxiety-like behaviors and peripheral insulin resistance. Treatment with metformin reversed the anxious phenotype without affecting insulin resistance, suggesting a complex interplay between apelin signaling, metabolic state, and emotional behavior.
Apelin deficiency leads to age- and metabolic state-dependent alterations in emotional behaviors, with implications for understanding mood disorders and metabolic diseases.
Apelin Knockout (Apelin⁻/⁻) mice generated to study the effects of apelin deficiency on emotional behavior across different ages and metabolic states.
Emotional behavior, Apelin, Anxiety, Depression, Metabolic state, Insulin resistance
Knockout model, Apelin deficiency, Age-dependent analysis, High-fat diet, Behavioral phenotyping
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