Apelin controls emotional behavior in age- and metabolic state-dependent manner

S Bullich
Université de Toulouse
March 7, 2022
Psychoneuroendocrinology
https://pubmed.ncbi.nlm.nih.gov/35305406

This article is currently being updated. View its version on PubMed.

https://pubmed.ncbi.nlm.nih.gov/35305406

Research summary

This study investigates the role of apelin, an adipokine, in modulating emotional behaviors in mice, considering age and metabolic state. Utilizing apelin Knockout (Apelin⁻/⁻) mice, researchers observed that 12-month-old Apelin⁻/⁻ mice exhibited an antidepressant-like phenotype under standard diet conditions. Conversely, 6-month-old Apelin⁻/⁻ mice on a high-fat diet displayed increased anxiety-like behaviors and peripheral insulin resistance. Treatment with metformin reversed the anxious phenotype without affecting insulin resistance, suggesting a complex interplay between apelin signaling, metabolic state, and emotional behavior.

Key outcome of the study

Apelin deficiency leads to age- and metabolic state-dependent alterations in emotional behaviors, with implications for understanding mood disorders and metabolic diseases.

Model

Apelin Knockout (Apelin⁻/⁻) mice generated to study the effects of apelin deficiency on emotional behavior across different ages and metabolic states.

TARGET:
Apln
Synonyms:
Apelin

Keywords

Emotional behavior, Apelin, Anxiety, Depression, Metabolic state, Insulin resistance

Technical specifications

Knockout model, Apelin deficiency, Age-dependent analysis, High-fat diet, Behavioral phenotyping

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